Results 91 to 100 of about 750,133 (244)

Curvature‐Directed Elongation and Chiral Tilting Drive Asymmetric Tissue Patterning

Advanced Science, EarlyView.
Curvature and cell handedness together break tissue symmetry. On convex and concave surfaces, cells elongate along opposite geometric axes and tilt in a consistent chirality‐driven direction, yielding opposite alignment patterns from the same cells. Reversing intrinsic cell chirality reverses both.
Liyao Xu, Frank Daniel Peters, Haokang Zhang, Madison Stiefbold, Thangam Ramar, Aditya Agarwal, Leo Q. Wan   +6 more
wiley   +1 more source

Investigating the role of nuclear myosin I in the low serum induced repositioning of chromosome 10 in interphase nuclei [PDF]

, 2010
This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.The nucleus of mammalian cells has been proven to be highly organised.
Amira, Manelle
core   +4 more sources

Search for inhibitors of myosin ATP-ase activity using molecular modeling

, 2009
З використанням методiв молекулярного моделювання знайдено сполуки, якi мають високий рiвень передбачуваної спорiдненостi до мiозину i можуть бути конкурентними iнгiбiторами його АТФазної активностi.Compounds, having a high level of the predicted ...
Бориско, П.О., Судаков, О.О., Прилуцький, Ю.І.   +2 more
core   +1 more source

Myosin Inhibitors for Hypertrophic Obstructive Cardiomyopathy (HOCM): Is HOCM passing another Crossroad?

Lawrenz T, Lawin D, Stellbrink C. Myosin Inhibitors for Hypertrophic Obstructive Cardiomyopathy (HOCM): Is HOCM passing another Crossroad?
Lawrenz, Thorsten, Lawin, Dennis, Stellbrink, Christoph   +2 more
core   +1 more source

Detection of myosin light chain phosphorylation - A cell-based assay for screening Rho-kinase inhibitors

, 2008
Here, we describe the first example of a cell-based myosin light chain phosphorylation assay in 96-well format that allows for the rapid screening of novel Rho-kinase inhibitors. We obtained IC50 values for the prototypic Rho-kinase inhibitors Y-27632 (1.
Schroeter, Thomas, LoGrasso, Philip, Griffin, Evelyn, Weiser, Amiee, Feng, Yangbo   +4 more
core   +1 more source

Microelectromechanical System Measurement of Platelet Contraction: Direct Interrogation of Myosin Light Chain Phosphorylation

, 2021
Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP).
Leland J. Spangler, Henry Caplan, Charles S. Cox, Mitchell J. George, Brijesh S. Gill, Julia Litvinov, Kevin Aroom, Charles E. Wade   +7 more
core   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Novel drugs targeting genetic variants: current applications and future prospects in heart failure treatment

Frontiers in Molecular Biosciences
Chronic heart failure (HF) is a common and frequently occurring disease worldwide, and its traditional treatment methods are undergoing earth-shaking changes.
Xiang Li, Suwen Bai, Yumei Luo
doaj   +1 more source

Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis [PDF]

, 2009
The final step during cell division is the separation of daughter cells, a process that requires the coordinated delivery and assembly of new membrane to the cleavage furrow.
Manuel Rauch, Naissant, B., Sabine Thiberge, Langsley, G., Fathia Ben Rached, Ben Rached, F., Meissner, M., Rauch, M., Angelika Kretzschmar, Agop-Nersesian, C., Kretzschmar, A., David J P Ferguson, Menard, R., Markus Meissner, David J. P. Ferguson, Carolina Agop-Nersesian, Robert Menard, Thiberge, S., Gordon Langsley, Ferguson, D.J.P., Bernina Naissant, Thiberge Sabine, Menard Robert, Kretzschmar Angelika, Naissant Bernina, Meissner Markus, Agop-Nersesian Carolina, Ferguson David J. P., Langsley Gordon, Rached Fathia Ben, Rauch Manuel   +30 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source