Results 81 to 90 of about 750,133 (244)
Advanced Science, EarlyView.Mechanisms of Fatty Infiltration and Muscle Degeneration. Clinical metadata identified intramuscular fat accumulation as an independent driver of muscle mass decline. Single‐nucleus RNA sequencing of spinal sarcopenia muscle revealed adipogenic reprogramming of fibro‐adipogenic progenitors, satellite‐cell niche disruption, and elevated levels of the ...
Wenkai Wu +18 more
wiley +1 more source
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases
Frontiers in Pharmacology, 2017 Myosin light chain kinase (MLCK) induces contraction of the perijunctional apical actomyosin ring in response to phosphorylation of the myosin light chain.
Yongjian Xiong +7 more
doaj +1 more source
The role of myosin II in stabilizing actin tethers promoting GLUT4 exocytosis in 3T3-L1 adipocytes [PDF]
, 2018 Aberrant insulin signaling results in an impaired ability to clear glucose from the bloodstream, which progresses to type II diabetes mellitus once insulin stimulation no longer results in a significant decrease in blood glucose levels.
Nikouyeh, Jonah B. +1 more
core
Advanced Science, EarlyView.This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang +14 more
wiley +1 more source
In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain [PDF]
, 2007 Intracellular movement is a fundamental property of all cell types. Many organelles and molecules are actively transported throughout the cytoplasm by molecular motors, such as the dimeric type V myosins.
Mulvihill, Daniel P. +6 more
core +1 more source
Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids
Advanced Science, EarlyView.This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia +8 more
wiley +1 more source
Localization of Myosin II and identification of its potential upstream regulators in Dictyostelium discoideum [PDF]
, 2015 The thesis work presented here aimed to understand how myosin II is regulated in Dictyostelium discoideum within the context of chemotactic signaling and cell migration.
Herring, Ashley +1 more
core
Myosin-II and cytosolic mCherry during migration under microfluidic confinement.
, 2016 (A) Myosin-II accumulates at the cortex in confined Dictyostelium cells, while (B) mCherry, used as a volume marker, does not show cortical/membrane enrichment at 1.7 μm.
Zachary R. Gagnon (3196320) +3 more
core +1 more source
A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects
Advanced Science, EarlyView.Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song +13 more
wiley +1 more source