Results 201 to 210 of about 50,966 (244)
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In vitro and in vivo effects of inhibitors on actin and myosin
Bioorganic and Medicinal Chemistry, 2021The interaction of actin and myosin is essential for cell migration. We have identified kaempferol and pentahalogenated pseudilins as efficient inhibitors of migration of MDA-MB-231 breast adenocarcinoma cells. The compounds were studied with respect to possible effects on myosin-2-ATPase activity.
Hans-Joachim Knölker, Herwig O Gutzeit
exaly +3 more sources
Cardiac Myosin Inhibitors: Expanding the Horizon for Hypertrophic Cardiomyopathy Management
Annals of Pharmacotherapy, 2023Objective: To review the current literature on the efficacy and safety of cardiac myosin inhibitors (CMIs) for the treatment of hypertrophic cardiomyopathy (HCM). Data Sources: A literature search was conducted on PubMed from origin to
Alyssa Sykuta +5 more
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Blebbistatin, a Myosin II Inhibitor, Is Photoinactivated by Blue Light
Biochemistry, 2004Blebbistatin is a small molecule inhibitor discovered in a screen for inhibitors of nonmuscle myosin IIA. Blebbistatin inhibits the actin-activated MgATPase activity and in vitro motility of class II myosins. In cells, it has been shown to inhibit contraction of the cytokinetic ring.
Takeshi, Sakamoto +4 more
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2,3-Butanedione monoxime (BDM) as a myosin inhibitor
Journal of Muscle Research & Cell Motility, 20022,3-Butanedione monoxime (BDM) is the well-characterized, low-affinity, non-competitive inhibitor of skeletal muscle myosin-II. It has been widely used at millimolar concentrations in cell biological experiments with the assumption that it is an ATPase inhibitor of the myosin superfamily. To determine the usefulness of BDM as a general myosin inhibitor,
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A small-molecule inhibitor of skeletal muscle myosin II
Nature Cell Biology, 2001We screened a small-molecule library for inhibitors of rabbit muscle myosin II subfragment 1 (S1) actin-stimulated ATPase activity. The best inhibitor, N-benzyl-p-toluene sulphonamide (BTS), an aryl sulphonamide, inhibited the Ca2+-stimulated S1 ATPase, and reversibly blocked gliding motility.
A, Cheung +6 more
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The development of novel myosin inhibitors
2011This thesis describes a structure activity relationship (SAR) study on the recently discovered small molecule tool blebbistatin (S)-21 with particular emphasis on the development of novel synthetic protocols suitable for the rapid synthesis of libraries of blebbistatin analogues.
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Advances in Cardiovascular Pharmacotherapy. I. Cardiac Myosin Inhibitors
Journal of Cardiothoracic and Vascular AnesthesiaHypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. The disease is characterized by asymmetric left ventricular (LV) remodeling with myocyte disarray and interstitial fibrosis, a hypercontractile state, dynamic subaortic obstruction of the LV outflow tract, impaired LV diastolic function, atrial and ventricular arrhythmias ...
Paul S, Pagel +3 more
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The Revolution of Cardiac Myosin Inhibitors in Patients With Hypertrophic Cardiomyopathy
Canadian Journal of CardiologyHypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy worldwide and causes significant morbidity and mortality. For decades, medical treatment options have been limited and untargeted, with frequent need for invasive interventions not readily accessible to many HCM patients.
Rebecca Haraf, Hany Habib, Ahmad Masri
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Myosin inhibitor flexes, myosin activator flops
Nature Reviews Drug Discovery, 2020openaire +1 more source