Results 211 to 220 of about 750,133 (244)

Reprogramming of Human Limbal Niche Progenitors. [PDF]

Int J Med Sci
Guo X, Wang W, Wilde A, Zhu Y, Li G.
europepmc   +1 more source

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

Targeting cardiac myosin in HFrEF: mechanism, clinical evidence, and the role of omecamtiv mecarbil. [PDF]

J Cardiothorac Surg
Abady E, Elewa M, Karam KN, Mathew KT, Bedair M, Almashaqbeh SN, Alwarraqi AG, AbuEl-Enien H, Samadi Y, Abouelmad K.   +9 more
europepmc   +1 more source

Genotype‐Informed Whole‐Animal Kinome Screening Reveals Shared Kinase Vulnerabilities Across Driver Contexts in PDAC

Cancer Science, EarlyView.
Overview of experimental workflow and key findings. Clinically prevalent 2‐hit and 3‐hit PDAC genotypes were first modeled in Drosophila to enable kinome‐wide genetic screening. Candidate therapeutic targets were prioritized using human tumor expression data and pathway enrichment analyses.
Han Hai, Takako Ooshio, Hui Jiang, Taku Kimura, Yusuke Satoh, Soichiro Hata, Taiga Hirata, Jiayi Liu, Tongwei Liu, Ryodai Yamamura, Masahiro Sonoshita   +10 more
wiley   +1 more source

Effects of chemical myosin II cross-bridge inhibitors on eccentric force production in skinned muscle fibres. [PDF]

Exp Physiol
Tomalka A, Weidner S, Rode C, Siebert T.
europepmc   +1 more source

Purpurin Alleviates Meniscal Senescence and Osteoarthritis by Blocking the Non‐Metabolic Function of Hexokinase 2

Cell Proliferation, EarlyView.
HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin, Ming Li, Wei Li, Tianfa Xu, Zongrui Jiang, Yanlin Zhong, Aishan He, Xiaoyi Zhao, Dianbo Long, Yan Kang   +9 more
wiley   +1 more source

Hypertrophic Cardiomyopathy is a Disease of Sarcomere Proteins. [PDF]

Methodist Debakey Cardiovasc J
Marian AJ.
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Hypertrophic cardiomyopathy: state of the art on diagnosis and current therapeutic approach. [PDF]

Cardiovasc Ultrasound
La Franca E, Parisi F, Lucchino A, Sade LE, Wong T, Loddo I, Alioto L, Gentile G, Pilato M, Cipriani M, Faletra FF.   +10 more
europepmc   +1 more source

The Impact of Aging on the Tongue Proteome. [PDF]

Muscles
Ohlendieck K, Zweyer M, Nebeling F, Swandulla D, Dowling P.   +4 more
europepmc   +1 more source