Results 81 to 90 of about 61,568 (292)

Alu Overexpression Leads to an Increased Double‐stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, Accepted Article.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non‐coding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Pediatric myositis ossificans circumscripta following traumatic hip dislocation: A case report

Radiology Case Reports, 2023
Myositis ossificans is non-neoplastic heterotopic bone forms in skeletal muscle. We recognize 3 subtypes: fibrodysplasia ossificans progressiva, myositis ossificans with no history of trauma (nontraumatic or pseudomalignant), and circumscribed or ...
Khadija Laasri, MD, Siham El Haddad, PhD, Salma Marrakchi, MD, Ismail Mohamed Halfi, MD, Nazik Allali, PhD, Latifa Chat, PhD   +5 more
doaj  

First‐Line Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Retrospective, Multicenter, Real‐World Study

Head &Neck, EarlyView.
ABSTRACT Background In Europe, pembrolizumab with or without chemotherapy is the recommended first‐line treatment for recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), with a combined positive score (CPS) ≥ 1. In France, the TPExtreme (TPEx) regimen is preferred for CPS < 1.
Alizée Simon, Cyril Abdeddaim, DucTrung Nguyen, Patrice Gallet, Didier Peiffert, Aurélien Lambert, Lionnel Geoffrois   +6 more
wiley   +1 more source

Myositis Autoantibodies: A Comparison of Results From the Oklahoma Medical Research Foundation Myositis Panel to the Euroimmun Research Line Blot

Arthritis & Rheumatology, 2020
The ability to accurately assay a broad range of well-defined autoantibody specificities in myositis patients is imperative for clinical phenotyping and patient care.
C. Mecoli, J. Albayda, E. Tiniakou, Julie J. Paik, U. Zahid, S. Danoff, L. Casciola-Rosen, M. Casal-Dominguez, K. Pak, I. Pinal‐Fernandez, A. Mammen, L. Christopher‐Stine   +11 more
semanticscholar   +1 more source

Mitochondrial dysfunction: Related diseases, influencing factors, and detection

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction is implicated in the pathogenesis of numerous diseases, including neurological disorders, cancers, and cardiovascular conditions, through mechanisms such as mitochondrial DNA mutations, dysregulation of mitochondrial network dynamics, and impaired mitophagy.
Zhaojin Li, Shiyu Li, Wanying Chen, Ziyu Zhang, Chun Pan, Peng Lei, Cheng Cheng, Junyou Zhu, Hanxiao Sun, Zhenning Dai   +9 more
wiley   +1 more source

Muscle Ultrasound

Journal of Ultrasound in Medicine, EarlyView.
Objectives This study aims to investigate the potential use of noninvasive muscle ultrasound (US) for detecting early‐developing insulin resistance and lower muscle mass in adults with obesity. Methods Twenty subjects with obesity, without type 2 diabetes mellitus or prediabetes (mean body mass index [BMI] 34.1 ± 3.1 kg/m2, mean age 33 years, 65% male),
Steven B. Soliman, Olivia K. Chugh, Jacob E. Leuteneker, Becca Tuska, Wen Ye, Tao Zhang, Thomas Rode, Suzette M. Howton, Eric D. Buras, Jeffrey F. Horowitz   +9 more
wiley   +1 more source

Increased Cardiac Troponin T May Be a Marker of Worsening Skeletal Myopathy in Inclusion Body Myositis: A Case Report

Cardiology Discovery
. Previous studies have reported elevated cardiac troponin T (cTnT) in patients with inclusion body myositis due to skeletal myopathy. Although the trends of cTnT have been reported in some cases, the onset of elevation has barely been reported.
Zhiqing Fu, Xiujin Zhang, Hanjia Gao
doaj   +1 more source

High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort

Pediatric Rheumatology Online Journal, 2011
Inflammatory myositis is reported in 4-16% of adult systemic lupus erythematosus (SLE) patients. The aim of this study was to determine the prevalence of myositis in a cohort of pediatric SLE patients in the southeastern United States.
Cron Randy Q, Beukelman Timothy, Record Jessica L   +2 more
doaj   +1 more source

Highly differentiated cytotoxic T cells in inclusion body myositis.

Brain : a journal of neurology, 2019
Inclusion body myositis is a late onset treatment-refractory autoimmune disease of skeletal muscle associated with a blood autoantibody (anti-cN1A), an HLA autoimmune haplotype, and muscle pathology characterized by cytotoxic CD8+ T cell destruction of ...
S. Greenberg, J. Pinkus, S. Kong, C. Baecher-Allan, A. Amato, D. Dorfman   +5 more
semanticscholar   +1 more source

Myositis autoantibodies [PDF]

Current Opinion in Rheumatology, 2012
To review recent advances in our understanding of autoantibodies associated with dermatomyositis and the autoimmune necrotizing myopathies.Autoantibodies preferentially associated with dermatomyositis include those recognizing Mi-2, MDA5, TIF1γ, and NXP-2. Each of these is associated with a distinct clinical phenotype.
Livia, Casciola-Rosen, Andrew L, Mammen
openaire   +2 more sources