Results 241 to 250 of about 33,582 (263)
Some of the next articles are maybe not open access.
European Journal of Sport Science, 2020
Fibroblast growth factor 21 (FGF-21) and myostatin have been proposed to be potential therapeutic target for insulin resistance in age-related metabolic disorders including type 2 diabetes (T2D).
F. Shabkhiz +4 more
semanticscholar +1 more source
Fibroblast growth factor 21 (FGF-21) and myostatin have been proposed to be potential therapeutic target for insulin resistance in age-related metabolic disorders including type 2 diabetes (T2D).
F. Shabkhiz +4 more
semanticscholar +1 more source
Identification of the Minimum Peptide from Mouse Myostatin Prodomain for Human Myostatin Inhibition
Journal of Medicinal Chemistry, 2015Myostatin, an endogenous negative regulator of skeletal muscle mass, is a therapeutic target for muscle atrophic disorders. Here, we identified minimum peptides 2 and 7 to effectively inhibit myostatin activity, which consist of 24 and 23 amino acids, respectively, derived from mouse myostatin prodomain. These peptides, which had the propensity to form
Kentaro, Takayama +12 more
openaire +2 more sources
Scandinavian Journal of Medicine & Science in Sports, 2011
Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were obtained from young male subjects before and after 30 and 90 days of resistance training as well as after 3, 10, 30, 60 and 90 days of subsequent detraining. Myostatin mRNA increased
J G, Jespersen +4 more
openaire +2 more sources
Myostatin is a potent negative regulator of skeletal muscle mass, but its role in human skeletal muscle hypertrophy and atrophy is sparsely described. Muscle biopsies were obtained from young male subjects before and after 30 and 90 days of resistance training as well as after 3, 10, 30, 60 and 90 days of subsequent detraining. Myostatin mRNA increased
J G, Jespersen +4 more
openaire +2 more sources
Expression of myostatin, myostatin receptors and follistatin in diabetic rats submitted to exercise
Clinical and Experimental Pharmacology and Physiology, 2012Summary Myostatin (MSTN) has been implicated in metabolic adaptation to physiological stimuli, such as physical exercise, which is linked to improved glucose homeostasis. The aim of the present study was to evaluate the influence of exercise on the expression of MSTN, MSTN receptors (ActRIIB and ALK4) and follistatin (FS) in the muscle and fat of ...
Daniela B, Dutra +6 more
openaire +2 more sources
Human Physiology, 2018
In recent years, there has been an increasing interest in myostatin, a hormone that inhibits the growth and differentiation of muscle tissue. This interest is associated with an increase in the amount of data on the spectrum of the myostatin functioning.
D. S. Kostyunina +2 more
openaire +1 more source
In recent years, there has been an increasing interest in myostatin, a hormone that inhibits the growth and differentiation of muscle tissue. This interest is associated with an increase in the amount of data on the spectrum of the myostatin functioning.
D. S. Kostyunina +2 more
openaire +1 more source
Myostatin inhibits differentiation of bovine preadipocyte
Domestic Animal Endocrinology, 2007We investigated the effect of myostatin on the differentiation of bovine preadipocyte. Stromal-vascular cells containing preadipocytes were prepared from perirenal adipose tissue of approximately 30-month-old Japanese Black steers. After confluence, the differentiation was induced by 1-methyl-3-isobutyl-xanthine, dexamethasone, insulin, and ...
Shizuka, Hirai +5 more
openaire +2 more sources
Myostatin in Muscle Growth and Repair
Exercise and Sport Sciences Reviews, 2001Myostatin, a member of the TGF beta superfamily, regulates skeletal muscle size by controlling embryonic myoblast proliferation. Recent results show that myostatin may also have a role in muscle regeneration and muscle wasting of adult animals. This review summarizes the recent developments in the regulation of myostatin gene expression and mechanism ...
M, Sharma +3 more
openaire +2 more sources
Prolonged absence of myostatin reduces sarcopenia
Journal of Cellular Physiology, 2006AbstractSarcopenia is a progressive age‐related loss of skeletal muscle mass and strength. Parabiotic experiments show that circulating factors positively influence the proliferation and regenerative capacity of satellite cells in aged mice. In addition, we believe that negative regulators of muscle mass also serve to balance the signals that influence
Victoria, Siriett +5 more
openaire +2 more sources
Myostatin regulation during skeletal muscle regeneration
Journal of Cellular Physiology, 2000Myostatin, a member of the TGF-beta superfamily, is a key negative regulator of skeletal muscle growth. The role of myostatin during skeletal muscle regeneration has not previously been reported. In the present studies, normal Sprague-Dawley and growth hormone (GH)-deficient (dw/dw) rats were administered the myotoxin, notexin, in the right M.
S, Kirk +5 more
openaire +2 more sources
Muscle regeneration through myostatin inhibition
Current Opinion in Rheumatology, 2005Myostatin is an endogenous, negative regulator of muscle growth. Selective inhibition of myostatin may have broad clinical utility by improving regeneration in diverse and burdensome muscle disorders. An understanding of this potential is relevant because inhibitors of myostatin have recently entered clinical trials.This article reviews the structure ...
openaire +2 more sources