Results 71 to 80 of about 1,270,049 (189)
Muscle &Nerve, Volume 74, Issue 3, Page 656-668, September 2026.ABSTRACT Introduction/Aims Oculopharyngeal muscular dystrophy (OPMD) is a neuromuscular disease presenting with dysphagia, ptosis, and proximal weakness. Muscle strength and indoor mobility capacity have rarely been studied using standardized clinical outcome assessments (COAs). The objectives of this study were to (1) document muscle strength, balance,
Nicolas Bélair +11 more
wiley +1 more source
BMC Neurology, 2019 Background Non-dystrophic myotonias (NDMs) are skeletal muscle disorders involving myotonia distinct from myotonic dystrophy. It has been reported that the muscle pathology is usually normal or comprises mild myopathic changes in NDMs.
Takanori Hata +7 more
doaj +1 more source
Technologies for engineering repetitive DNA
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Repetitive DNA, a fundamental architectural element of genomes, is widespread across organisms and comprises about 54% of the human genome. With advances in long‐read sequencing and bioinformatics approaches, highly repetitive sequences can now be characterized in depth.
Shuting Ma, Yali Cui, Yi Wu
wiley +1 more source
Small Science, Volume 6, Issue 9, September 2026.A biomimetic 3D human skeletal muscle microtissue platform is developed by integrating primary young and aged SkMCs with muscle‐derived dECM and 3D‐printed PCL anchors. Aged constructs recapitulate selected biological and functional hallmarks of skeletal muscle aging, including impaired myotube formation, mitochondrial alterations, calcium handling ...
Sohae Yang +9 more
wiley +1 more source
Traffic, Volume 27, Issue 3, September 2026.Clathrin plaques (magenta) form large, flat membrane‐associated lattices embedded within the cortical actin cytoskeleton, and can be distinguished from individual clathrin‐coated pits (yellow). These structures are surrounded by a dense network of actin filaments and associated proteins, illustrating the intimate structural coupling between clathrin ...
Marion Benoist, Stéphane Vassilopoulos
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 18, Page 7739-7771, 15 September 2026.Abstract figure legend We investigated the effects of piperine on (1) the structure of the resting thick filament and (2) dynamic contractility in fibres and intact slow (soleus) and fast (extensor digitorum longus, EDL) rat muscles, respectively. The structure of the resting thick filament was assessed pre‐ and post‐piperine incubation using small ...
Daniel Z. Kruse +5 more
wiley +1 more source
Anesthesia for a Patient with Myotonic Dystrophy
, 2016 Myotonic dystrophy is the most common myotonic syndrome causing abnormalities of the skeletal and smooth muscles as well as problems related to the cardiac, gastrointestinal and endocrine systems. In affected people, reduced functional residual capacity,
Dilek Kalaycı +6 more
core +1 more source
Functions of the Muscleblind-like protein family and their role in disease
Cell Communication and SignalingConserved proteins are characterized by their functions remaining nearly constant throughout evolutionary history, both vertically through time and horizontally across species.
Hui Zhou, Jiachi Xu, Liusheng Pan
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Myotonic Dystrophy—A Progeroid Disease?
Frontiers in Neurology, 2018 Myotonic dystrophies (DM) are slowly progressing multisystemic disorders caused by repeat expansions in the DMPK or CNBP genes. The multisystemic involvement in DM patients often reflects the appearance of accelerated aging. This is partly due to visible
Peter Meinke +3 more
doaj +1 more source
TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats
Cell Reports, 2018 Summary: Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington’s disease. Because expansions trigger the disease, contracting repeat length could be
Valentine Mosbach +4 more
doaj +1 more source