Results 11 to 20 of about 10,687,918 (152)

The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C-Terminal Regions. [PDF]

Proteins
ABSTRACT Intrinsically disordered regions (IDRs) of proteins remain understudied with enigmatic sequence features relevant to their functions. Members of the myotubularin‐related protein (MTMR) family contain uncharacterized IDRs. After decades of research on their phosphatase activity, recent work on the C‐terminal IDRs of MTMR7 ...
Saar D, Lennartsson CLE, Weidner P, Burgermeister E, Kragelund BB.   +4 more
europepmc   +6 more sources

The human myotubularin-related protein suppresses the growth of lung carcinoma cells

Oncology Reports, 2004
Herein, we report that the human myotubularin-related protein (KIAA0371) induced growth suppression of lung cancer cells. Colony formation assays demonstrated that the exogenous expression of the human myotubularin-related gene induced a significant growth inhibition of H1299 cells in which the expression of the human myotubularin-related gene was ...
Young Do, Yoo, Sun Mi, Cho, Jun Suk, Kim, Yoon Soo, Chang, Chul Min, Ahn, Hyung Jung, Kim   +5 more
openaire   +4 more sources

Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2

Nature Genetics, 2000
A gene mutated in Charcot-Marie-Tooth disease type 4B (CMT4B), an autosomal recessive demyelinating neuropathy with myelin outfoldings, has been mapped on chromosome 11q22. Using a positional-cloning strategy, we identified in unrelated CMT4B patients mutations occurring in the gene MTMR2, encoding myotubularin-related protein-2, a dual specificity ...
Bolino A, Muglia M, Conforti FL, LeGuern E, Salih MA, Georgiou DM, Christodoulou K, HausmanowaPetrusewicz I, Mandich P, Schenone A, Gambardella A, Bono F, Quattrone A, Devoto M, Monaco AP   +14 more
core   +7 more sources

Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt [PDF]

Cell Death & Disease, 2020
AbstractCardiac hypertrophy (CH) is an independent risk factor for many cardiovascular diseases, and is one of the primary causes of morbidity and mortality in elderly people. Pathological CH involves excessive protein synthesis, increased cardiomyocyte size, and ultimately the development of heart failure. Myotubularin-related protein 14 (MTMR14) is a
Zhang, Jie-Lei, Zhang, Dian-Hong, Li, Ya-Peng, Wu, Lei-Ming, Liang, Cui, Yao, Rui, Wang, Zheng, Feng, Sheng-dong, Wang, Zhong-Min, Zhang, Yan-Zhou   +9 more
openaire   +2 more sources

OXPHOS complex deficiency in congenital myopathy: A systematic review. [PDF]

Eur J Clin Invest
This systematic review assessed oxidative phosphorylation (OXPHOS) complex dysfunction in genetically confirmed congenital myopathies (CM). Among 5841 studies screened, 23 publications, comprising 45 CM cases, met the inclusion criteria. OXPHOS dysfunction was identified in 78% of cases, particularly where enzymology was performed, with RYR1 most ...
du Preez MJ, Schoonen M, Williams ME, Bisschoff M, van der Westhuizen FH.   +4 more
europepmc   +2 more sources

Membrane targeting of sorting nexins and myotubularin related protein 3.

, 2005
Membrane targeting of sorting nexins and myotubularin related protein ...
Aura. Burian (7958858)
core   +4 more sources

Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3 [PDF]

Journal of Cell Science, 2005
The myotubularins are a large family of phosphoinositide-specific phosphatases with substrate specificity for PtdIns3P and PtdIns(3,5)P2. In addition to an N-terminal PH-GRAM (PH-G) domain and a signature catalytic domain shared with other family members, MTMR3 contains a C-terminal FYVE domain. We show that the FYVE domain of MTMR3 is atypical in that
Oscar, Lorenzo, Sylvie, Urbé, Michael J, Clague   +2 more
openaire   +2 more sources

PHLPP is neither a Phosphatase nor a Tumor Suppressor. [PDF]

Bioessays
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Leonard TA.
europepmc   +2 more sources

Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins [PDF]

Journal of Biological Chemistry, 2013
Bone morphogenetic proteins (BMPs) signaling essentially regulates a wide range of biological responses. Although multiple regulators at different layers of the receptor-effectors axis have been identified, the mechanisms of homeostatic BMP signaling remain vague.
Junjing, Yu, Xiaomeng, He, Ye-Guang, Chen, Yan, Hao, Shuo, Yang, Lei, Wang, Lei, Pan, Hong, Tang   +7 more
openaire   +2 more sources

Phosphatidylinositol-3 Phosphatase Myotubularin-Related Protein 6 Negatively Regulates CD4 T Cells [PDF]

Molecular and Cellular Biology, 2006
Intracellular Ca2+ levels rapidly rise following cross-linking of the T-cell receptor (TCR) and function as a critical intracellular second messenger in T-cell activation. It has been relatively under appreciated that K+ channels play an important role in Ca2+ influx into T lymphocytes by helping to maintain a negative membrane potential which provides
Shekhar, Srivastava, Kyung, Ko, Papiya, Choudhury, Zhai, Li, Amanda K, Johnson, Vivek, Nadkarni, Derya, Unutmaz, William A, Coetzee, Edward Y, Skolnik   +8 more
openaire   +2 more sources