Results 41 to 50 of about 29,137 (174)

Concomitant Medication Effects on Immunotherapy Outcomes in Sarcoma: A Pooled Post Hoc Analysis of Seven Phase II Trials

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Concomitant medications (CMs) influence outcomes in patients receiving immune checkpoint inhibitors (ICIs), but their impact in sarcoma remains undefined. We assessed the association between CM use and ICI outcomes in patients with advanced or metastatic sarcoma. Methods This pooled analysis included patients from seven investigator‐
Adel Shahnam, Kristen DiConza, Simran Jasnani, Rhoena Desir‐Camille, Evan Rosenbaum, Olayode Babatunde, Ciara M. Kelly, Lauren B. Banks, Viswatej Avutu, Ping Chi, Sujana Movva, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Robert G. Maki, William D. Tap, Sandra P. D'Angelo   +16 more
wiley   +1 more source

What's Your Diagnosis? Large Mediastinal Mass in a Dog

Veterinary Clinical Pathology, EarlyView.
Rosane O. Cruz, Talles M. Almeida, Iris D. S. Menezes, Ludmila R. Moroz, Suane N. Boaventura, Tiago Peixoto, Stella F. Valle, Nicole Hlavac   +7 more
wiley   +1 more source

Pleomorphic Leiomyosarcoma of the Jejunoileal Mesentery: A Histopathological Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Gastrointestinal leiomyosarcomas are rare malignancies. Herein, we present a case report of a previously healthy 60‐year‐old female presenting with periumbilical abdominal pain, vomiting, and difficulty in passing stool, with clinical workup, imaging, and surgery defining a small intestine tumor.
George S. Stoyanov, Zlatko Zlatev, Andrea Kirilova, Kristina Naydenova, Hristo Popov   +4 more
wiley   +1 more source

Neoadjuvant chemotherapy for soft‐tissue sarcoma of the extremities: A post‐hoc Sarculator‐based risk analysis of the EORTC 62961–ESHO 95 randomized trial

Cancer, Volume 132, Issue 9, 1 May 2026.
Abstract Background In the EORTC 62961–ESHO 95 randomized trial (European Organization for Research and Treatment 62961–European Society of Hyperthermia Oncology 95; ClinicalTrials.gov identifier NCT00003052), neoadjuvant chemotherapy (NAC) combined with regional hyperthermia (RHT) improved survival in patients with soft tissue sarcoma (tumor size >5 ...
Markus Albertsmeier, Valeria Milani, Lars H. Lindner, Gabriele Tinè, Sandro Pasquali, Dario Callegaro, Alessandro Gronchi, Hans‐Roland Dürr, Alexander Klein, Dorit Di Gioia, Sultan Abdel‐Rahman, Michael Schmidt, Jens Werner, Michael von Bergwelt‐Baildon, Rosalba Miceli, Rolf Issels   +15 more
wiley   +1 more source

Cardiac metastases from primary myxoid liposarcoma of the thigh: a case report

World Journal of Surgical Oncology, 2020
Background Myxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease.
Kunihiro Ikuta, Tomohisa Sakai, H. Koike, Tohru Okada, S. Imagama, Y. Nishida   +5 more
semanticscholar   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

JAK–STAT signalling controls cancer stem cell properties including chemotherapy resistance in myxoid liposarcoma

International Journal of Cancer, 2019
Myxoid liposarcoma (MLS) shows extensive intratumoural heterogeneity with distinct subpopulations of tumour cells. Despite improved survival of MLS patients, existing therapies have shortcomings as they fail to target all tumour cells.
S. Dolatabadi, Emma Jonasson, M. Lindén, Bentolhoda Fereydouni, Karin Bäcksten, M. Nilsson, A. Martner, Amin Forootan, H. Fagman, G. Landberg, P. Åman, A. Ståhlberg   +11 more
semanticscholar   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

Trabectedin and RAdiotherapy in Soft Tissue Sarcoma (TRASTS): Results of a Phase I Study in Myxoid Liposarcoma from Spanish (GEIS), Italian (ISG), French (FSG) Sarcoma Groups

EClinicalMedicine, 2019
Background Myxoid liposarcoma (ML) exhibits a special sensitivity to trabectedin (T) and radiation therapy (RT). Preclinical data suggest a synergistic effect.
A. Gronchi, N. Hindi, J. Cruz, J. Blay, A. López-Pousa, A. Italiano, R. Alvarez, A. Gutiérrez, I. Rincón, C. Sangalli, Jose Luis Pérez Aguiar, J. Romero, C. Morosi, M. Sunyach, R. Sanfilippo, C. Romagosa, D. Ranchère‐Vince, A. D. Dei Tos, P. Casali, J. Martín-Broto   +19 more
semanticscholar   +1 more source

Recurrent myxoid liposarcoma of the hand

Radiology Case Reports, 2020
Malignant hand tumors are rarely observed in clinical practice which makes distinguishing them from benign soft tissue masses particularly challenging. A 41-year-old male presented with joint pain and swelling of his left index metacarpophalangeal joint. Radiological studies showed pronounced swelling around the affected joint with no bony abnormality,
Carter J. Boyd, BS, Claire Davis, MD, Srikanth Kurapati, MD, Shivani Ananthasekar, BS, David Mateo de Acosta Andino, MD, Ali Kilic, MD   +5 more
openaire   +3 more sources