Results 41 to 50 of about 418,264 (199)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Caracterización del uso de antieméticos en el postoperatorio en pacientes adultos sometidos a cirugía durante el periodo enero-mayo 2009, en el Hospital Clínica Bíblica de Costa Rica Characterization of the Use of Antiemetics in the Postoperative Period in Adult Patients Undergoing Surgery During January to May 2009 in a private hospital Clínica Bíblica in Costa Rica

open access: yesActa Médica Costarricense, 2010
Objetivo: Evaluar y caracterizar el abordaje farmacoterapéutico antiemético en el periodo postoperatorio en pacientes adultos sometidos a cirugía en el Hospital Clínica Bíblica (hospital privado en Costa Rica).
Natalia Apuy-Roldán   +3 more
doaj  

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou   +6 more
wiley   +1 more source

Factores de riesgo de discapacidad moderada a grave por migraña.

open access: yesMultimed, 2017
RESUMEN Introducción: la migraña es la séptima causa de discapacidad laboral, doméstica y social en el mundo y es la principal causa de discapacidad entre las afecciones neurológicas.
Andrés José Quesada Vázquez   +2 more
doaj  

Nursing diagnosis “nausea” during chemotherapy: concept analysis

open access: yesRevista Eletrônica de Enfermagem, 2017
A study with the objective to analyze the concept nausea in chemotherapeutic treatment, to improve the nursing diagnosis “nausea”. We used the model proposed by Walker and Avant as a theoretical reference and, we conducted an integrative review in the ...
Aline Maria Bonini Moysés   +3 more
doaj   +1 more source

Individual Factors Contributing to Nausea in First-Time Chemotherapy Patients: A Prospective Cohort Study

open access: yesFrontiers in Pharmacology, 2019
ObjectiveThe expectation of developing side effects can enhance the likelihood to develop them – a phenomenon referred to as nocebo effect. Whether nocebo effects can be reduced by lowering negative expectancies, is not clear. The aim of this prospective
Karin Meissner   +11 more
doaj   +1 more source

Nausea: a review of pathophysiology and therapeutics

open access: yesTherapeutic Advances in Gastroenterology, 2016
The sensation of nausea is a common occurrence with diverse causes and a significant disease burden. Nausea is considered to function as a protective mechanism, warning the organism to avoid potential toxic ingestion. Less adaptive circumstances are also
Prashant Singh   +2 more
doaj   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

open access: yesAdvanced Functional Materials, EarlyView.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia   +12 more
wiley   +1 more source

O efeito do jazz em A Náusea de Jean-Paul Sartre

open access: yesArtefilosofia, 2017
O objetivo deste estudo é analisar e discutir o papel que a música exerce no romance A náusea de Jean-Paul Sartre. Assim, em um primeiro momento se irá descrever o modo como a contingência se apresenta na obra, para em um segundo momento explicitar o ...
Artur Ricardo de Aguiar Weidmann
doaj  

Melancolia e náusea: do destino enquanto fundamento do caráter trágico ao absurdo existencial

open access: yesTrans/Form/Ação, 2014
A partir da perspectiva intelectualista grega, na qual o dualismo entre corpo e alma requer o primado do discurso racional [lógos] em detrimento do páthos filosófico, busca-se com este artigo associar a noção de "desmedida" [hybris] com a noção de ...
Thiago Rodrigues
doaj   +1 more source

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