Results 61 to 70 of about 585,553 (296)

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Caracterización del uso de antieméticos en el postoperatorio en pacientes adultos sometidos a cirugía durante el periodo enero-mayo 2009, en el Hospital Clínica Bíblica de Costa Rica

Acta Médica Costarricense, 2010
Objetivo: Evaluar y caracterizar el abordaje farmacoterapéutico antiemético en el periodo postoperatorio en pacientes adultos sometidos a cirugía en el Hospital Clínica Bíblica (hospital privado en Costa Rica).
Natalia Apuy-Roldán, José Miguel Chaverri-Fernández, Mónica Monge-Aguilera, Esteban Zavaleta-Monestel   +3 more
doaj  

A experiência do non-sens em Roquentin: a Náusea sob as lentes da psicanálise

Aufklärung, 2020
O objetivo deste artigo é pensar o fenômeno da angústia, decorrente do ­non-sens conforme experienciado pelo personagem Roquentin, no livro A Náusea, de Sartre, buscando estabelecer uma leitura a partir de alguns conceitos da psicanálise de Freud e Lacan,
Renato Santos
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Caracterización del uso de antieméticos en el postoperatorio en pacientes adultos sometidos a cirugía durante el periodo enero-mayo 2009, en el Hospital Clínica Bíblica de Costa Rica Characterization of the Use of Antiemetics in the Postoperative Period in Adult Patients Undergoing Surgery During January to May 2009 in a private hospital Clínica Bíblica in Costa Rica

Acta Médica Costarricense, 2010
Objetivo: Evaluar y caracterizar el abordaje farmacoterapéutico antiemético en el periodo postoperatorio en pacientes adultos sometidos a cirugía en el Hospital Clínica Bíblica (hospital privado en Costa Rica).
Natalia Apuy-Roldán, José Miguel Chaverri-Fernández, Mónica Monge-Aguilera, Esteban Zavaleta-Monestel   +3 more
doaj  

Analgesia pós-operatória imediata por infiltração de bupivacaína 0,25% com epinefrina em ferida de colecistectomia aberta: um ensaio clínico randomizado

Revista de Medicina da UFC, 2017
Objetivo: avaliar a analgesia e algumas variáveis associadas ao bem-estar pós-operatório como náuseas e vômitos em pacientes submetidos à infiltração de bupivacaína 0,25% com epinefrina em ferida operatória de colecistectomia aberta comparados ao grupo ...
Ítalo Aguiar Freire, Gerardo Cristino de Menezes Neto, Roberto Vinícius de Carvalho Lima, Vicente de Paulo Pinto Teixeira   +3 more
doaj   +1 more source

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Factores de riesgo de discapacidad moderada a grave por migraña.

Multimed, 2017
RESUMEN Introducción: la migraña es la séptima causa de discapacidad laboral, doméstica y social en el mundo y es la principal causa de discapacidad entre las afecciones neurológicas.
Andrés José Quesada Vázquez, Alexis Álvarez Aliaga, Julio Cesar González Aguilera   +2 more
doaj  

Comparação da qualidade de vida de portadores de câncer de pulmão antes e após o tratamento quimioterápico [PDF]

, 2013
OBJECTIVE: this prospective study aimed to assess the quality of life related to health (QLRH) of patients with lung cancer after chemotherapy treatment.
Belasco, Angélica Gonçalves Silva, Bettencourt, Ana Rita de Cassia, Oliveira, Priscila Isolani de, Pereira, Carlos Alberto de Castro   +3 more
core   +4 more sources