Results 71 to 80 of about 288,653 (253)

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

Advanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen, Dunfang Liu, Jiahui Jin, Han Yao, Yao Sheng, Yarong Liu, Jingwei Sun, Yang Yang   +7 more
wiley   +1 more source

Avaliação de dessincronia atrioventricular em portadores de marca-passo bicameral devido à doença do nó sinusal e bloqueio atrioventricular de primeiro grau [PDF]

, 2017
Andrés Di Leoni Ferrari
openalex   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science, EarlyView.
This study develops the hydrogel with antimicrobial, adhesive, degradable, injectable, and temperature‐sensitive contraction properties based on the transcriptomic and pathological characteristics of intestinal fistula patients. This hydrogel can seal rabbit intestinal fistula in situ, reduce the intestinal defect, and promote intestinal epithelial ...
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
wiley   +1 more source

Implante de marcapasso cardíaco definitivo em paciente com síndrome bradicardia-taquicardia, transplantado renal e com persistência de veia cava superior esquerda

Journal of Cardiac Arrhythmias, 2014
A persistência da veia cava superior esquerda é rara, principalmente quando associada a ausência da veia cava superior direita, e mais ainda quando associada a síndrome bradicardia-taquicardia.
Marcelo Vier Gambetta, Fábio Rech da Costa   +1 more
doaj   +4 more sources

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Prognostic Value of Serum Insulin‐Like Growth Factor‐1 in Patients With Anal Fistula Treated by Incision‐Thread‐Drawing Surgery

Annals of Gastroenterological Surgery, EarlyView.
IGF‐1 levels above 174.9 ng/mL were associated with better wound healing and lower postoperative inflammation. Higher IGF‐1 levels correlated with improved anal function at 7 and 14 days post‐surgery. ABSTRACT Background Anal fistula is a chronic condition characterized by an abnormal tract between the anal canal and perianal skin, often leading to ...
Zhijun Wu, Xuexue Yin, Jing Li
wiley   +1 more source

Conjugated Polymer Composite Flexible Wood Hydrogel‐Mediated Sequential NIR‐II Photothermal and Photodynamic Anti‐Bacteria and Macrophage Polarization for Acute Sinusitis

Aggregate, EarlyView.
This study developed a D–A–D–A conjugated polymer with NIR‐II absorption for phototherapy. The conjugated polymer nanoparticles were functionalized with hemin and embedded in a wood‐based hydrogel (LM@P/S@CP@Hemin). In MRSA‐infected rabbit sinusitis models, the NIR‐II laser treatment showed outstanding antibacterial effect, reduced inflammation, and ...
Lei He, Xiaofeng Ma, Yongze Liu, Genyuan Li, Juqing Cui, Jun Zhang, Yuanyuan Li, Ben Zhong Tang, Wentao Wang   +8 more
wiley   +1 more source

Advances in Organic In‐Sensor Neuromorphic Computing: from Material Mechanisms to Applications

Advanced Intelligent Discovery, EarlyView.
This review discusses organic in‐sensor neuromorphic computing for wearable and bioelectronic systems, with a focus on memory‐based and OECT‐based synaptic devices. It highlights key design principles, recent advances, and existing challenges. By integrating sensing and processing within organic materials, the approach enables real‐time, low‐power, and
Dong Hyun Lee, Woojo Kim, Eun Kwang Lee, Hocheon Yoo   +3 more
wiley   +1 more source

Custom Shape Formation in Continuum Robots Using Compliant Bistable Segments for Medical Applications

Advanced Intelligent Systems, EarlyView.
This article describes the integration of compliant bi‐stability in continuum robots. This integration leads to two variants of compliant bistable mechanism (CBM) integrated continuum robot segments, extending and locking. Results show that when used together, these CBM‐integrated segments allow the continuum robot to form custom shapes.
Muhammad Umer Khan Niazi, Usman Mehmood, Jaesoon Choi, Yoon Se Lee, Youngjin Moon   +4 more
wiley   +1 more source