Results 1 to 10 of about 116,528 (325)

Identification of a serotonin N-acetyltransferase from Staphylococcus pseudintermedius ED99 [PDF]

Frontiers in Microbiology, 2023
Serotonin N-acetyltransferase (SNAT) catalyzes the biosynthesis of N-acetylserotonin (NAS) and N-acetyltryptamine (NAT), two pleiotropic molecules with neurotransmitter functions.
Nourhane Hafza, Nourhane Hafza, Ningna Li, Arif Luqman, Friedrich Götz, Friedrich Götz   +5 more
doaj   +2 more sources

Exploring the role of N-acetyltransferases in diseases: a focus on N-acetyltransferase 9 in neurodegeneration [PDF]

Neural Regeneration Research
Acetyltransferases, required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.
Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Amit Singh   +2 more
doaj   +2 more sources

An N-acetyltransferase required for ESAT-6 N-terminal acetylation and virulence in Mycobacterium marinum [PDF]

mBio, 2023
N-terminal protein acetylation is a ubiquitous post-translational modification that impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this modification in ...
Owen A. Collars, Bradley S. Jones, Daniel D. Hu, Simon D. Weaver, Taylor A. Sherman, Matthew M. Champion, Patricia A. Champion   +6 more
doaj   +2 more sources

N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye [PDF]

Cell Death and Disease, 2023
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests as accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of neurofibrillary tangles (NFTs) that results in microtubule destabilization.
Prajakta Deshpande, Anuradha Venkatakrishnan Chimata, Emily Snider, Aditi Singh, Madhuri Kango-Singh, Amit Singh   +5 more
doaj   +2 more sources

Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT) [PDF]

eLife
Degradation of heparan sulfate (HS), a glycosaminoglycan (GAG) comprised of repeating units of N-acetylglucosamine and glucuronic acid, begins in the cytosol and is completed in the lysosomes.
Vikas Navratna, Arvind Kumar, Jaimin K Rana, Shyamal Mosalaganti   +3 more
doaj   +2 more sources

N-acetyltransferase AAC(3)-I confers gentamicin resistance to Phytophthora palmivora and Phytophthora infestans [PDF]

BMC Microbiology, 2019
Background Oomycetes are pathogens of mammals, fish, insects and plants, and the potato late blight agent Phytophthora infestans and the oil palm and cocoa infecting pathogen Phytophthora palmivora cause economically impacting diseases on a wide range of
Edouard Evangelisti, Temur Yunusov, Liron Shenhav, Sebastian Schornack   +3 more
doaj   +2 more sources

N-acetyltransferase 10 mediates cognitive dysfunction through the acetylation of GABA_BR1 mRNA in sepsis-associated encephalopathy. [PDF]

Proc Natl Acad Sci U S A
Gao S, Shen R, Li J, Jiang Y, Sun H, Wu X, Li X, Miao C, He M, Wang J, Chen W.   +10 more
europepmc   +2 more sources

560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment

Frontiers in Pharmacology, 2022
Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). Genetic
Mark A. Doll, David W. Hein
doaj   +1 more source

NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +2 more sources

NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +2 more sources