Biotechnology and Bioengineering, EarlyView.The probiotic E. coli Nissle 1917 was engineered to enable stable and antibiotic free protein expression platforms using native plasmids. Further modification aids in the production of high‐level protein expression for antimicrobial secretion whose activity is comparable to industry standard E. coli BL21.
Halimatun Sakdiah Zainuddin +2 more
wiley +1 more source
An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii [PDF]
, 1997 Philip N. Rather +2 more
openalex +1 more source
An Orthogonal Way of Writing the Tubulin Code
Cytoskeleton, EarlyView.ABSTRACT The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells.
Vicente Jose Planelles‐Herrero +1 more
wiley +1 more source
Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex [PDF]
, 2001 Tomáš Obšil +4 more
openalex +1 more source
Human arylamine N-acetyltransferase 2 genotype-dependent protein expression in cryopreserved human hepatocytes [PDF]
, 2020 Raúl A. Salazar‐González +2 more
openalex +1 more source
Phenotyping of N -acetyltransferase type 2 and xanthine oxidase with caffeine: when should urine samples be collected? [PDF]
, 2018 Objectives: Individual activities of N-acetyltransferase 2 (NAT2) and of xanthine oxidase (XO) can be assessed using ratios of urinary caffeine metabolites.
Fuhr, Uwe +5 more
core
Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis
Clinical Pharmacology &Therapeutics, EarlyView.Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic +4 more
wiley +1 more source
Distribution of xenobiotic metabolising enzyme genotypes in different Tunisian populations
Annals of Human Biology, 2017 Background: The N-acetyltransferase 2 (NAT2) and glutathione transferase enzymes play a crucial role in the metabolism of xenobiotics. Genetic polymorphisms affecting these enzymes can modify their activities with an effect on individual susceptibility ...
Slah Ouerhani +3 more
doaj +1 more source
COSMOS 2044. Experiment K-7-19. Pineal physiology in microgravity: Relation to rat gonadal function [PDF]
It is now known that the pineal organ can interact with many endocrine and nonendocrine tissues in a regulatory fashion. Given its key role in the regulation of melatonin synthesis, its high concentration, and that its levels may persist longer than the ...
Asadi, H. +3 more
core +1 more source
PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature
Clinical Pharmacology &Therapeutics, EarlyView.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou +14 more
wiley +1 more source