Results 11 to 20 of about 116,528 (325)

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
A Tostmann, Atikaimu Wubuli, B Roy, B Roy, C Benichou, Corinne Merle, D Yee, DL Zhu, DS Huang, DW Hein, H Devarbhavi, HG Xie, HJ Cho, HJ De Rosa, HR An, HR An, I Vieira, J Meyer D, JH Wang, Jiayi Gu, Jinfeng Ma, JJ Saukkonen, JN Hirschhorn, JN Pande, JR Mitchell, JR Mitchell, Lei Yang, LG Possuelo, Long Ma, M Dossing, M Guo, M Guo, M Ingelman-Sundberg, M Ohno, M Runge-Morris, Mark Patrick Nicol, Mingqin Cao, N Vuilleumier, Paul Milligan, PD Bose, PD Roy, Qian Wang, Qian Wang, R Shakya, RC Strange, RL Teixeira, S Chatterjee, S Huang Y, S Russmann, S Sunahara, S Yamada, SH Kim, SH Kim, SK Sharma, SW Lee, SW Tang, T Mohri, T Sotsuka, T Wang, T Wang, T Yamamoto, V Leiro, Wei Liu, Weidong Wu, WJ Burman, WM Lee, WW Yew, Xia Zhu, Xiumei Xin, Xuemei Yao, XZ Lv, Y Chen, Yang Xiang, Ying Mao, YM Wu, Yongguang Li, YS Huang, YS Huang, YS Huang, YS Huang   +79 more
core   +14 more sources

A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity

RNA Biology, 2023
Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated.
Felina Lenkeit, Iris Eckert, Malte Sinn, Franziskus Hauth, Jörg S. Hartig, Zasha Weinberg   +5 more
doaj   +1 more source

The Vibrio cholerae SpeG Spermidine/Spermine N-Acetyltransferase Allosteric Loop and β6-β7 Structural Elements Are Critical for Kinetic Activity

Frontiers in Molecular Biosciences, 2021
Polyamines regulate many important biological processes including gene expression, intracellular signaling, and biofilm formation. Their intracellular concentrations are tightly regulated by polyamine transport systems and biosynthetic and catabolic ...
Van Thi Bich Le, Sofiya Tsimbalyuk, Ee Qi Lim, Allan Solis, Darwin Gawat, Paloma Boeck, Ee Qing Lim, Rosselini Renolo, Jade K. Forwood, Misty L. Kuhn   +9 more
doaj   +1 more source

Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism

Pharmaceutics, 2020
UV light catalyzes the ozone formation from air pollutants, like nitrogen oxides. Since ozone reacts with cutaneous sebum lipids to peroxides and, thus, promotes inflammation, tumorigenesis, and aging, even broad-spectrum sunscreens cannot properly ...
Renata Spagolla Napoleão Tavares, Silvya Stuchi Maria-Engler, Pio Colepicolo, Hosana Maria Debonsi, Monika Schäfer-Korting, Uwe Marx, Lorena Rigo Gaspar, Christian Zoschke   +7 more
doaj   +1 more source

From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2. [PDF]

PLoS ONE, 2014
Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we describe experiments demonstrating that human arylamine N-acetyltransferase Type 1 and its murine ...
Nicola Laurieri, Julien Dairou, James E Egleton, Lesley A Stanley, Angela J Russell, Jean-Marie Dupret, Edith Sim, Fernando Rodrigues-Lima   +7 more
doaj   +1 more source

Human N-Acetyltransferase 1 and 2 Differ in Affinity Towards Acetyl-Coenzyme A Cofactor and N-Hydroxy-Arylamine Carcinogens

Frontiers in Pharmacology, 2022
Arylamine N-acetyltransferases catalyze the transfer of acetyl groups from the endogenous cofactor acetyl coenzyme A (AcCoA) to arylamine (N-acetylation) and N-hydroxy-arylamine (O-acetylation) acceptors.
David W. Hein, Mark A. Doll, Mariam R. Habil   +2 more
doaj   +1 more source

Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2

Frontiers in Pharmacology, 2022
Many cancers, including breast cancer, have shown differential expression of human arylamine N-acetyltransferase 1 (NAT1). The exact effect this differential expression has on disease risk and progression remains unclear.
Samantha M. Carlisle, Samantha M. Carlisle, Patrick J. Trainor, Patrick J. Trainor, Mark A. Doll, David W. Hein   +5 more
doaj   +1 more source

Population pharmacokinetic model of isoniazid in patients with tuberculosis in Tunisia

International Journal of Infectious Diseases, 2021
Aims: To develop a pharmacokinetic model of isoniazid (INH) concentration taking into account demographic factors and genetic variables [N-acetyltransferase 2 (NAT2) genotype], and to propose an initial INH dosage that could maximize the probability of ...
N. Ben Fredj, H. Ben Romdhane, J.B. Woillard, M. Chickaid, N. Ben Fadhel, Z. Chadly, A. Chaabane, N. Boughattas, K. Aouam   +8 more
doaj   +1 more source

Doxorubicin-Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake [PDF]

, 2020
Doxorubicin (DOX) is an effective anthracycline antibiotic drug which is commonly used in a broad range cancer therapy. However, due to dose depending side effects and toxicity to non-cancerous tissues, its clinical applications are restricted.
Bäumler, Hans, Chaiwaree, Saranya, Georgieva, Radostina, Laporte, Tomás, Neumann, Tanja, Prapan, Ausanai, Pruß, Axel, Suwannasom, Nittiya   +7 more
core   +1 more source

Arylamine N-Acetyltransferases in Mycobacteria [PDF]

Current Drug Metabolism, 2008
Polymorphic Human arylamine N-acetyltransferase (NAT2) inactivates the anti-tubercular drug isoniazid by acetyltransfer from acetylCoA. There are active NAT proteins encoded by homologous genes in mycobacteria including M. tuberculosis, M. bovis BCG, M. smegmatis and M. marinum. Crystallographic structures of NATs from M. smegmatis and M.
Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble MEM   +8 more
openaire   +3 more sources