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Expert Opinion on Drug Metabolism & Toxicology, 2007
Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following
Sim, Edith +2 more
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Arylamine N-acetyltransferases (NATs), known as drug- and carcinogen-metabolising enzymes, have had historic roles in cellular metabolism, carcinogenesis and pharmacogenetics, including epidemiological studies of disease susceptibility. NAT research in the past 5 years builds on that history and additionally paves the way for establishing the following
Sim, Edith +2 more
openaire +3 more sources
Arylamine N-acetyltransferase I
The International Journal of Biochemistry & Cell Biology, 2007Arylamine N-acetyltransferase I (NAT1) is a phase II enzyme that acetylates a wide range of arylamine and hydrazine substrates. The NAT1 gene is located on chromosome 8 and shares homology to NAT genes found in most mammalian species. Gene expression occurs from at least two promoters and a number of tissue-specific transcripts have been identified ...
Minchin, RF +5 more
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Nomenclature for N-acetyltransferases
Pharmacogenetics, 1995A consolidated classification system is described for prokaryotic and eukaryotic N-acetyltransferases in accordance with the international rules for gene nomenclature. The root symbol (NAT) specifically identifies the genes that code for the N-acetyltransferases, and NAT* loci encoding proteins with similar function are distinguished by Arabic numerals.
Kostas P. Vatsis +12 more
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Arylamine N-Acetyltransferases
Toxicology, 2008Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which
Butcher, Neville J., Minchin, Rodney F.
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1994
Human variability in drug acetylation was discovered nearly four decades ago during the initial clinical trials of isoniazid as an antituberculosis drug (reviewed in Weber 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite its effectiveness, a high proportion (3.5%–17%) of treated patients developed a devastating, progressive ...
K. P. Vatsis, W. W. Weber
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Human variability in drug acetylation was discovered nearly four decades ago during the initial clinical trials of isoniazid as an antituberculosis drug (reviewed in Weber 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite its effectiveness, a high proportion (3.5%–17%) of treated patients developed a devastating, progressive ...
K. P. Vatsis, W. W. Weber
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N-Acetyltransferase Polymorphism in Thailand
Human Heredity, 1984A series of 222 individuals from the northeastern provinces of Thailand were studied with respect to acetylator phenotypes. Among individuals of pure Thai descent 55.5% were rapid acetylators. The corresponding figure for Chinese was 66.0%. There were no significant differences between Thais and Chinese.
V, Kukongviriyapan +4 more
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Regulation of Arylamine N-Acetyltransferases
Current Drug Metabolism, 2008Acetylation catalysed by the arylamine N-acetyltransferases (NATs; 2.3.1.5) is a major biotransformation pathway for arylamine and hydrazine drugs, as well as many carcinogens that we are exposed to on a daily basis. These compounds can either be detoxified by NATs or bioactivated to metabolites that have the potential to cause toxicity such as cancer.
Butcher, Neville J. +2 more
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