Results 81 to 90 of about 116,528 (325)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Supplementary Table 2 from N-acetyltransferase 2 Phenotype, Occupation, and Bladder Cancer Risk: Results from the EPIC Cohort [PDF]

, 2023
Beate Pesch, Katarzyna Gawrych, Sylvia Rabstein, Tobias Weiß, Swaantje Casjens, Hans‐Peter Rihs, Hui Ding, J. Angerer, Thomas Illig, Norman Klopp, Bas Bueno‐de‐Mesquita, Martine M. Ros, Rudolf Kaaks, Jenny Chang‐Claude, Nina Roswall, Anne Tjønneland, Kim Overvad, Françoise Clavel-Chapelon, Marie‐Christine Boutron‐Ruault, Laure Dossus, Heiner Boeing, Steffen Weikert, Dimitrios Trichopoulos, Domenico Palli, Sabina Sieri, ­Rosario ­Tumino, Salvatore Panico, J. Ramón Quirós, Carlos A. González, María‐José Sánchez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte, Börje Ljungberg, Mattias Johansson, David Ulmert, Roy Ehrnström, Kay‐Tee Khaw, Nicholas J. Wareham, Timothy J. Key, Pietro Ferrari, Isabelle Romieu, Elio Ríboli, Thomas Brüning, Paolo Vineis   +44 more
openalex   +1 more source

Transcriptome profiling of grapevine seedless segregants during berry development reveals candidate genes associated with berry weight [PDF]

, 2016
Indexación: Web of Science; PubMedBackground Berry size is considered as one of the main selection criteria in table grape breeding programs. However, this is a quantitative and polygenic trait, and its genetic determination is still poorly understood ...
A Doligez, A Roberts, A Zamboni, AJ Bais, Alejandro Maass, Alex Di Genova, AM Almeida, AP Friend, Ariel Orellana, AS Negri, BG Coombe, BG Coombe, BG Coombe, BM Fischer, C Chen, C Conde, C Houel, C Pastore, C Pratt, C Sweetman, C Trapnell, CA Ledbetter, Claudia Muñoz-Espinoza, D Costenaro da Silva, D Lijavetzki, D Moreno, D Schenck, DH Lorenz, F Carrari, F Dyda, FG Silva da, FJ Pérez, G Fanizza, GR Cramer, I Debeaujon, J Correa, J Correa, J Guo, J Tello, J Xu, JA Cabezas, José Correa, JP Nitsch, K Chen, K Yang, KCH Amrine, L Bogrë, L Costantini, L Deluc, L Fernandez, M Barticevic, M Chakrabarti, M Fasoli, M González-Agüero, M Lu, M Rienth, M Salmaso, Mauricio González-Agüero, MB Ali, MC Palumbo, MJ Carmona, MJ Martínez-Esteso, MK Aradhya, N Mejía, N Mejía, N Schumann, N Wang, N Yokotani, NS Watson-Haigh, O Gudenschwager, O Jaillon, P Barba, P Langcake, P Neudecker, P Nicolas, Patricio Hinrichsen, R Core Team, R Ursem, Romina Silva, S Dal Santo, S Epskamp, S Guillaumie, S Lê, S Myles, S Taylor, S Zenoni, SBP Athauda, T Sekito, T Wei, X Chen, Z Du   +90 more
core   +3 more sources

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Estimation of N-acetyltransferase 2 haplotypes [PDF]

N-Acetyltransferase 2 (NAT2) genotyping may result in a considerable percentage in several ambiguous allele combinations. PHASE 2.1 is a statistical program which is designed to estimate the probability of different allele combinations.
Blaszkewicz, Meinolf, Bolt, Hermann M., Dannappel, Doris, Golka, Klaus, Samimi, Mirabutaleb, Selinski, Silvia   +5 more
core  

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis

Sultan Qaboos University Medical Journal, 2003
Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A ...
Musbah O. M. Tanira, Mehmet Simsek, Khalid Al Balushi, Khulood Al Lawatia, Hameedah Al Barawani, Riad A. Bayoumi   +5 more
doaj