Results 171 to 180 of about 3,713 (189)

Synthesis, Antibiofilm Activity and Molecular Docking of N-Acylhomoserine Lactones Containing Cinammic Moieties

Bioorganic & Medicinal Chemistry Letters, 2023
We prepared a series of cinnamoyl-containing furanones by an affordable and short synthesis. The nineteen compounds hold a variety of substituents including electron-donating, electron-withdrawing, bulky and meta-substituted phenyls, as well as heterocyclic rings. Compounds showed antibiofilm activity in S. aureus, K.
Ángel Ramírez-Trinidad, Ernesto Martínez-Solano, César E. Tovar-Roman, Mariana García-Guerrero, José A. Rivera-Chávez, Eduardo Hernández-Vázquez   +5 more
openaire   +2 more sources

BpiB05, a novel metagenome-derived hydrolase acting on N-acylhomoserine lactones

Journal of Biotechnology, 2011
The N-acyl-homoserine lactones (N-AHLs) play an important role in bacterial cell-cell signaling. Up to date, however, only a few different experimentally proven classes of N-AHL ring-cleaving enzymes are known. Here we report on the isolation and biochemical characterization of a novel hydrolase derived from the soil metagenome and acting on N-AHLs ...
P, Bijtenhoorn, C, Schipper, C, Hornung, M, Quitschau, S, Grond, N, Weiland, W R, Streit   +6 more
openaire   +2 more sources

Plants genetically modified to produce N-acylhomoserine lactones communicate with bacteria

Nature Biotechnology, 1999
N-acylhomoserine lactones (AHLs) play a critical role in plant/microbe interactions. The AHL, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL), induces exoenzymes that degrade the plant cell wall by the pathogenic bacterium Erwinia carotovora. Conversely, the antifungal activity of the biocontrol bacterium Pseudomonas aureofaciens 30-84 is due (at least ...
R G, Fray, J P, Throup, M, Daykin, A, Wallace, P, Williams, G S, Stewart, D, Grierson   +6 more
openaire   +2 more sources

N-acylhomoserine lactone-degrading Bacillus strains isolated from aquaculture animals

Aquaculture, 2011
Abstract Infections caused by antibiotic-resistant pathogenic bacteria can cause considerable losses in aquaculture. Many aquaculture pathogens regulate the expression of virulence genes through quorum sensing, bacterial cell-to-cell communication with small signal molecules. N-acyl homoserine lactones (AHLs) are the most extensively studied class of
Tom Defoirdt, Loan Doan Thanh, Bart Van Delsen, Peter De Schryver, Patrick Sorgeloos, Nico Boon, Peter Bossier   +6 more
openaire   +1 more source

Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase

Journal of Biotechnology, 2003
Porcine kidney acylase I was shown to be able to deacylate N-acylhomoserine lactones, a family of chemicals employed by Gram-negative bacteria as quorum-sensing molecules for cell population density-dependent growth (such as biofilm formation). The enzyme transformed both N-butyryl-and N-octanoyl-L-homoserine lactones into L-homoserine.
Feng, Xu, Tony, Byun, Heinz-Josef, Deussen, Kyle R, Duke, Heinz-Josef, Dussen   +4 more
openaire   +2 more sources

Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?

Microbiology, 2004
A number of bacteria, including some significant pathogens, utilize N-acylhomoserine lactones (AHLs) as quorum sensing signals. There is considerable interest in the therapeutic potential of disrupting quorum sensing. Recently, a number of bacteria have been identified which are capable of enzymic inactivation of AHLs.
Declan M, Roche, Joseph T, Byers, Debra S, Smith, Freija G, Glansdorp, David R, Spring, Martin, Welch   +5 more
openaire   +2 more sources

Modelled microgravity cultivation modulates N-acylhomoserine lactone production in Rhodospirillum rubrum S1H independently of cell density

Microbiology, 2013
The photosynthetic alphaproteobacterium Rhodospirillum rubrum S1H is part of the Micro-Ecological Life Support System Alternative (MELiSSA) project that is aiming to develop a closed life support system for oxygen, water and food production to support human life in space in forthcoming long-term space exploration missions.
Felice, Mastroleo, Rob, Van Houdt, Steve, Atkinson, Max, Mergeay, Larissa, Hendrickx, Ruddy, Wattiez, Natalie, Leys   +6 more
openaire   +2 more sources

Discovering Additional Chemical and Biological Functions for 3-Oxo-N-Acylhomoserine Lactones

2010
Introduction The term quorum sensing has been coined to describe the ability of a population of unicellular bacteria to act as a multicellular organism in a cell-density-dependent manner, that is, a way to sense “how many are out there” [1]. Bacteria use small diffusible molecules to exchange information amongst themselves.
Gunnar F. Kaufmann, Rafaella Sartorio, Sang-Hyeup Lee, Claude J. Rogers, Michael M. Meijler, Jason A. Moss, Bruce Clapham, Andrew P. Brogan, Tobin J. Dickerson, Kim D. Janda   +9 more
openaire   +1 more source

LuxR-dependent quorum sensing: Computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones

Bioorganic & Medicinal Chemistry Letters, 2010
A virtual screening, involving flexible docking sequences within the LuxR, TraR and LasR binding sites, was used as a structural binding sites similarity filter to specifically target conserved residues in the proteins of the LuxR family (namely Tyr62, Trp66, Tyr70, Asp79, Trp94 for LuxR).
Soulère, Laurent, Sabbah, Mohamad, Fontaine, Fanny, Queneau, Yves, Doutheau, Alain   +4 more
openaire   +3 more sources