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6.12 Detection, Purification, and Synthesis of n-acylhomoserine Lactone Quorum Sensing Signal Molecules

1998
Publisher Summary This chapter describes the most relevant practical approaches for the identification and characterization of the N-acylhomoserine lactones (AHL) family of quorum sensing signal molecules. The first indication of AHL-mediated gene regulation in a Gram-negative bacterial pathogen is the appearance of a specific phenotype in a cell ...
Miguel Càmara, Mavis Daykin, Siri Ram Chhabra   +2 more
openaire   +1 more source

Facile preparation of deuterium-labeled N-acylhomoserine lactones as internal standards for isotope dilution mass spectrometry

Bioorganic & Medicinal Chemistry, 2010
N-Acylhomoserine lactones (AHLs) are widely conserved signal molecules that mediate quorum sensing in Gram-negative bacteria. In this study, deuterium-labeled AHLs were prepared for use as internal standards for isotope dilution mass spectrometry. Their utility in the sensitive and precise quantification of AHLs in culture supernatants of bacteria by ...
Kenji, Kai, Ayaka, Tani, Hideo, Hayashi
openaire   +2 more sources

Distribution and characterization of N-acylhomoserine lactone (AHL)-degrading activity and AHL lactonase gene (qsdS) in Sphingopyxis

Journal of Bioscience and Bioengineering, 2019
N-Acylhomoserine lactone (AHL)-degrading enzyme is identified from the various environments and applied for quorum-sensing inhibition. In this study, we isolated two AHL-degrading strains, Sphingopyxis sp. EG6 and FD7, from the industrial cooling water samples.
Tomohiro, Morohoshi, Yaoki, Kamimura, Niina, Sato, Taro, Iizumi   +3 more
openaire   +2 more sources

Cell aggregation is negatively regulated by N-acylhomoserine lactone-mediated quorum sensing in Pantoea ananatis SK-1

Journal of Bioscience and Bioengineering, 2011
Pantoea ananatis SK-1 produces N-acylhomoserine lactones (AHLs) and regulates expression of some virulence factors through AHL-mediated quorum sensing. In this study, we discovered that the strain SK-02I, which has a disrupted AHL-synthetic gene, showed constitutive cell aggregation.
Tomohiro, Morohoshi, Yuji, Ogata, Tsukasa, Ikeda   +2 more
openaire   +2 more sources

Inhibitory control of quorum sensing using N-acylhomoserine lactone lactonase

Journal of Bioscience and Bioengineering, 2009
Takamasa Murai, Tomohiro Morohoshi, Hiroshi Motohashi, Azumi Kobayashi, Tsukasa Ikeda, Norihiro Kato   +5 more
openaire   +1 more source

The hydrolysis of unsubstituted N-acylhomoserine lactones to their homoserine metabolites

Journal of Chromatography A, 2007
Matthias Englmann, Agnes Fekete, Christina Kuttler, Moritz Frommberger, Xiaojing Li, Istvan Gebefügi, Jenoe Fekete, Philippe Schmitt-Kopplin   +7 more
openaire   +1 more source

Corrigendum to “Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase”

Journal of Biotechnology, 2003
Feng Xu, Tony Byun, Heinz-Josef Deussen, Kyle R. Duke   +3 more
openaire   +1 more source

N-Acylhomoserine Lactone-Mediated Quorum Sensing In Yersinia

2003
openaire   +1 more source

Induction of entry into the stationary growth phase in Pseudomonas aeruginosa by N-acylhomoserine lactone

FEMS Microbiology Letters, 1998
openaire   +1 more source