Results 121 to 130 of about 1,131 (161)

The Use of N, N-Diethyl-m-Toluamide to Enhance Dermal and Transdermal Delivery of Drugs

Journal of Pharmaceutical Sciences, 1982
A dermal penetration enhancer has been found which improves the dermal delivery of a wide variety of drugs and at the same time has a history of low toxicity for human dermal application. N,N-Diethyl-m-toluamide (I) has been shown to improve the delivery of many drugs through hairless mouse skin in an in vitro diffusion cell model.
J J Windheuser
exaly   +3 more sources

Electrochemical degradation of N,N-diethyl-m-toluamide on a boron-doped diamond electrode

Journal of the Taiwan Institute of Chemical Engineers, 2014
Abstract This study investigates the electrochemical oxidation of N,N-diethyl-m-toluamide (DEET) on a boron-doped diamond (BDD) anode under different temperatures, current densities, and sample matrixes. For comparison, a commercial Pt electrode and a lab-prepared PbO 2 anode were also tested.
Te-San Chen, Kuo-Lin Huang
exaly   +2 more sources

Decomposition of N, N-diethyl-m-toluamide by water plasma with mist generation

Journal of Environmental Chemical Engineering, 2022
Manabu Tanaka, Myeong-Hoon Lee, Takayuki Watanabe   +2 more
exaly   +2 more sources

Association of N, N-diethyl-m-toluamide (DEET) with hyperuricemia among adult participants

Chemosphere, 2023
N,N-diethyl-m-toluamide (DEET) is a widely used active ingredient in insect repellents, and its effects on human health have been a matter of debate. This study aims to investigate the relationship between DEET exposure and hyperuricemia in the adult population.Our study utilized a cross-sectional design and analyzed data from adult participants of the
Runmiao, Wu, Xu, Zhu, Yujie, Xing, Gongchang, Guan, Yong, Zhang, Rutai, Hui, Qianwei, Cui, Zhongwei, Liu, Ling, Zhu   +8 more
openaire   +2 more sources

Reversible inhibition of the urea cycle and gluconeogenesis by N,N-diethyl-m-toluamide

Biochemical and Biophysical Research Communications, 1991
Addition of DEET to suspensions of rat hepatocytes completely abolished synthesis of urea from ammonia and production of glucose from lactate. Both activities were fully restored after cells were washed and resuspended in DEET-free medium. These results suggest the DEET-induced impairment is a reversible biochemical defect at a site common to both ...
C M, Brini, G C, Tremblay
openaire   +2 more sources

Schistosomiasis prophylaxis in vivo using N,N-Diethyl-m-toluamide (DEET)

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2003
Topical N,N-Diethyl-m-toluamide (DEET) was studied as a schistosomiasis prophylactic in vivo for the use of individuals with limited exposure. Fifteen subjects, on a 3-week expedition to Lake Malawi in September 2001, applied 50% DEET to their skin after exposure to lake water. No subjects developed evidence of a new infection at 3-month follow-up.
F, Jackson, J F, Doherty, R H, Behrens
openaire   +2 more sources

In Vitro Human Metabolism and Interactions of Repellent N,N-Diethyl-m-Toluamide

Drug Metabolism and Disposition, 2002
Oxidative metabolism of the insect repellent N,N-diethyl-m-toluamide (DEET) by pooled human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) was investigated. DEET is metabolized by cytochromes P450 (P450s) leading to the production of a ring methyl oxidation product, N,N-diethyl-m-hydroxymethylbenzamide (BALC), and ...
Khawja A, Usmani, Randy L, Rose, Joyce A, Goldstein, Wesley G, Taylor, Alan A, Brimfield, Ernest, Hodgson   +5 more
openaire   +2 more sources

Fenvalerate/N,N-diethyl-m-toluamide (Deet) toxicosis in two cats

Journal of the American Veterinary Medical Association, 1990
Toxicosis attributable to fenvalerate and N,N-diethyl-m-toluamide (Deet) exposure was suspected in 2 cats. Clinical signs of toxicosis developed within 4 to 6 hours of dermal application of the pesticide. Clinical signs of toxicosis seen in both cats included hypersalivation, ataxia, and depression. In addition, seizures were seen in 1 cat.
D C, Dorman, W B, Buck, H L, Trammel, R D, Jones, V R, Beasley   +4 more
openaire   +2 more sources

Microencapsulation decreases the skin absorption of N,N-diethyl-m-toluamide (DEET)

Toxicology in Vitro, 2008
The insect repellent N,N-diethyl-3-methylbenzamide (DEET) is widely used and is generally regarded as safe when used according to label instructions. Yet many studies have shown it to be absorbed through the skin. The objective of this study was to determine whether the skin absorption rate of DEET could be decreased while maintaining an evaporation ...
Gerald B, Kasting, Varsha D, Bhatt, Tycho J, Speaker   +2 more
openaire   +2 more sources