Results 41 to 50 of about 15,352,997 (261)

Herpes simplex virus type 2: epidemiology and management options in developing countries [PDF]

, 2007
Genital herpes simplex virus type 2 (HSV2) is highly prevalent worldwide and an increasingly important cause of genital ulcer disease (GUD). Continued HSV2 transmission is facilitated by the large number of undiagnosed cases, the frequency of atypical ...
Geretti, AM, Paz-Bailey, G., Ramaswamy, M., Paz-Bailey, G, Hawkes, SJ, Hawkes, S. J., Geretti, A. M., Ramaswamy, M   +7 more
core   +1 more source

Randomized Simplicial Hessian Update

Mathematics, 2021
Recently, a derivative-free optimization algorithm was proposed that utilizes a minimum Frobenius norm (MFN) Hessian update for estimating the second derivative information, which in turn is used for accelerating the search.
Árpád Bűrmen, Tadej Tuma, Jernej Olenšek   +2 more
doaj   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

Conditions for the Existence of Absolutely Optimal Portfolios

Mathematics, 2021
Let Δn be the n-dimensional simplex, ξ = (ξ1, ξ2,…, ξn) be an n-dimensional random vector, and U be a set of utility functions. A vector x*∈ Δn is a U -absolutely optimal portfolio if EuξTx*≥EuξTx for every x∈ Δn and u ∈ U.
Marius Rădulescu, Constanta Zoie Rădulescu, Gheorghiță Zbăganu   +2 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Geometric Estimates in Interpolation on an n-Dimensional Ball

Моделирование и анализ информационных систем, 2019
Suppose \(n\in {\mathbb N}\). Let \(B_n\) be a Euclidean unit ball in \({\mathbb R}^n\) given by the inequality \(\|x\|\leq 1\), \(\|x\|:=\left(\sum\limits_{i=1}^n x_i^2\right)^{\frac{1}{2}}\).
Mikhail V. Nevskii
doaj   +1 more source

Structure Guides Function: Beyond Pairwise Neural Interactions. [PDF]

J Comp Neurol
Some neurons fire more to synchronous inputs than combination of isolated inputs predicts. This synergistic effect is largely invisible to pairwise measurements. We thus propose to represent neural circuits as hypergraphs, where edges connect three or more interacting neuronal structures, in addition to using lines for connected pairs.
Maier A.
europepmc   +2 more sources

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Reduction of HIV-1 RNA levels with therapy to suppress herpes simplex virus. [PDF]

, 2007
BACKGROUND: Epidemiologic data suggest that infection with herpes simplex virus type 2 (HSV-2) is associated with increased genital shedding of human immunodeficiency virus type 1 (HIV-1) RNA and HIV-1 transmissibility. METHODS: We conducted a randomized,
Becquart, Pierre, Van de Perre, Philippe, Sanon, Anselme, Segondy, Michel, Weiss, Helen A, Andonaba, Jean-Baptiste, Vallo, Roselyne, ANRS 1285 Study Group, Sawadogo, Adrien, Nagot, Nicolas, Foulongne, Vincent, Vergne, Laurence, Mayaud, Philippe, Ouédraogo, Abdoulaye, Defer, Marie-Christine, Djagbaré, Didier, Konaté, Issouf   +16 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source