Results 101 to 110 of about 1,481,196 (275)

Combining pair-density functional theory and variational two-electron reduced-density matrix methods

open access: yes, 2018
Complete active space self-consistent field (CASSCF) computations can be realized at polynomial cost via the variational optimization of the active-space two-electron reduced-density matrix (2-RDM).
DePrince III, A. Eugene   +1 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Quasi-({\lambda}; n)-distance-balanced graphs

open access: yes, 2019
Comment: 15 pages, 13 figures, this paper is prepared to submit to a journal in the ...
Pourhadi, Ehsan, Faghani, Morteza
openaire   +1 more source

Deuteron Structure at Small $N - N$ Distances from Inelastic $e-D$ and $p-D$ Reactions

open access: yes, 2001
The outline of the presentation is as follows: I. Nucleon Distribution in the Deuteron from $e-D$ and $p-D$ Processes. II. Quark Distribution in Deuteron from its Fragmentation to Pions and Deep Inelastic $e-D$ scattering. III.Difference of These Two Distributions and Its Possible Understanding.
Illarionov, A. Yu., Lykasov, G. I.
openaire   +2 more sources

Correlation length in cuprates deduced from the impurity-induced magnetization

open access: yes, 2004
We report a new multi-nuclei based NMR method which allows us to image the staggered polarization induced by nonmagnetic Li impurities in underdoped O6.6 and slightly overdoped O7 YBa2Cu3O6+y above T_C.
A. J. Millis   +9 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Distance, similarity and entropy measures of n-dimensional fuzzy sets

open access: yesMathematics in Applied Sciences and Engineering
An $n$-dimensional fuzzy set generalizes other fuzzy structures and effectively addresses real-world problems by providing greater flexibility in assigning membership values through the selection of an arbitrarily large $n$.
Jomal Josen, Sunil Jacob John, T. Baiju
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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