Results 1 to 10 of about 1,588 (96)

N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines [PDF]

Molecular Medicine
Background Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses.
Zhihua Li, Yatong Wu, Jicong Du, Wen Qian, Sinian Wang, Fengsheng Li, Suhe Dong, Shunchang Jiao   +7 more
doaj   +4 more sources

A novel in vitro cell model of the proteinase/antiproteinase balance observed in alpha-1 antitrypsin deficiency. [PDF]

Front Pharmacol
Background: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition resulting from mutations in the alpha-1 antitrypsin (AAT) protein, a major systemic antiproteinase, resulting in reduced/no release of AAT, disrupting the proteinase/antiproteinase ...
Chen CH, Crisford H, Scott A, Sapey E, Stockley RA.   +4 more
europepmc   +8 more sources

In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma [PDF]

Frontiers in Pharmacology, 2022
Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation.
Solveig Lemmel, Markus Weckmann, Markus Weckmann, Markus Weckmann, Anna Wohlers, Adan Chari Jirmo, Ruth Grychtol, Isabell Ricklefs, Isabell Ricklefs, Gyde Nissen, Gyde Nissen, Anna Bachmann, Shantanu Singh, Juan Caicedo, Thomas Bahmer, Thomas Bahmer, Gesine Hansen, Erika Von Mutius, Klaus F. Rabe, Oliver Fuchs, Oliver Fuchs, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Anne E. Carpenter, Matthias Volkmar Kopp, Matthias Volkmar Kopp, Matthias Volkmar Kopp, Tim Becker, Tim Becker, Tim Becker, the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), Mustafa Abdo, Miguel Alcazar, Thomas Bahmer, Mira Berbig, Heike Biller, Xenia Bovermann, Folke Brinkmann, Mifflin-Rae Calveron, Adan Chari Jirmo, David S. DeLuca, Gesa Diekmann, Anna-Maria Dittrich, Christian Dopfer, Markus Ege, Svenja Foth, Oliver Fuchs, Svenja Gaedcke, Karoline I. Gaede, Ruth Grychtol, Anika Habener, Gesine Hansen, Christine Happle, Christian Herzmann, Alexander Hose, Sabina Illi, Anne-Marie Kirsten, Naschla Kohistani-Greif, Inke R. König, Silke Van Koningsbruggen-Rietschel, Matthias V. Kopp, Johanna Kurz, Katja Landgraf-Rauf, Kristina Laubhahn, Lena Liboschik, Claudia Liebl, Berrit Liselotte Husstedt, Bin Liu, Nicole Maison, Aydin Malik, Carola Marzi, Meike Meyer, Erika Von Mutius, Gyde Nissen, Catharina Nitsche, Frauke Pedersen, Mareike Price, Klaus F. Rabe, Harald Renz, Isabell Ricklefs, Ernst Rietschel, Barbara Roesler, Bianca Schaub, Christina Schauberger, Tom Schildberg, Carsten Schmidt-Weber, Nicolaus Schwerk, Chrysanthi Skevaki, Alena Steinmetz, Laila Sultansei, Marlen Szewczyk, Dominik Thiele, Vera Veith, Gesche Voigt, Benjamin Waschki, Henrik Watz, Stefanie Weber, Markus Weckmann, Nils Welchering, Esther Zeitlmann, Ulrich Zissler   +102 more
doaj   +3 more sources

Preterm ETs Are Significantly Reduced Compared with Adults and Partially Reduced Compared with Term Infants [PDF]

Children, 2022
The release of DNA by cells during extracellular trap (ET) formation is a defense function of neutrophils and monocytes. Neutrophil ET (NET) formation in term infants is reduced compared to adults.
Aila Wirkner, Antje Vogelgesang, Ines Hegge, Anja Lange, Dirk Manfred Olbertz, Bernd Gerber, Matthias Heckmann, Johanna Ruhnau   +7 more
doaj   +2 more sources

Paralytic Impact of Centrifugation on Human Neutrophils [PDF]

Biomedicines, 2022
Centrifugation is a common step in most of the popular protocols for the isolation of neutrophils from whole blood. Inconsistent results from previous studies on neutrophils may originate from an underestimation of the centrifugation effect, as in ...
Tobias Hundhammer, Michael Gruber, Sigrid Wittmann   +2 more
doaj   +3 more sources

Influence of Acute Phase Proteins on Neutrophil Function In Vitro [PDF]

FASEB BioAdvances
As part of a systemic inflammatory response, acute phase proteins (APPs) are released into the blood to support the body's immune response. Once in the bloodstream, the APPs can also interact with immune cells, such as neutrophil granulocytes (PMNs ...
Richard F. Kraus, Isabell Wild, Michael A. Gruber, Martin G. Kees   +3 more
doaj   +2 more sources

Rapid autofluorescence flow cytometric analysis of agonist-induced neutrophil and eosinophil polarization reveals novel insights into 5-oxo-ETE-mediated granulocyte activation [PDF]

J Inflamm (Lond)
Minimizing unintended granulocyte activation while measuring functional responsiveness is essential, as the use of external probes, antibodies, or fluorescent dyes can potentially alter cellular responsiveness.
Fernando AJ, Rossi F, Docherty D, Popravko A, Masters L, Houston B, Gupta R, Dhaliwal K, Rossi AG.   +8 more
europepmc   +4 more sources

Effect of Arginine Vasopressin on Human Neutrophil Function Under Physiological and Sepsis-Associated Conditions. [PDF]

Int J Mol Sci
This study examines how different concentrations of arginine vasopressin (AVP) and its preservative chlorobutanol (ClB) impact the immune functions of human polymorphonuclear neutrophils (PMNs), which are crucial in the immune response, particularly in ...
Haile SM, Gruber M, Bollwein G, Trabold B.   +3 more
europepmc   +3 more sources

Protein O-GlcNAcylation in multiple immune cells and its therapeutic potential. [PDF]

Front Immunol, 2023
O-GlcNAcylation is a post-translational modification of proteins that involves the addition of O-GlcNAc to serine or threonine residues of nuclear or cytoplasmic proteins, catalyzed by O-GlcNAc transferase (OGT).
Cai H, Xiong W, Zhu H, Wang Q, Liu S, Lu Z.   +5 more
europepmc   +3 more sources

Primary sarcopenia is associated with elevated spontaneous NET formation [PDF]

Frontiers in Cell and Developmental Biology
Introduction: Sarcopenia is a frequent complication of liver cirrhosis, but it can also occur independently as a result of any underlying cause. The immune system plays an important role in the pathogenesis of both liver cirrhosis and sarcopenia ...
Irina Balazs, Irina Balazs, Manuel Stelzer, Julia Traub, Angela Horvath, Angela Horvath, Nicole Feldbacher, Nicole Feldbacher, Vanessa Stadlbauer, Vanessa Stadlbauer   +9 more
doaj   +2 more sources