Results 21 to 30 of about 1,607 (109)

Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis. [PDF]

Eur J Immunol
We investigated neutrophil heterogeneity in patients with systemic lupus erythematosus and identified increased surface levels of LAMP1 (CD107a). Stimulation of healthy donor neutrophils led to increased surface LAMP1. Urine and serum soluble LAMP1 levels were increased in patients, especially those with proliferative lupus nephritis.
Ostendorf L, Garantziotis P, Huang FY, Schett G, Accelerating Medicines Partnership: RA/SLE Network, Lederer JA, Fava A, Rao DA, Grieshaber-Bouyer R.   +8 more
europepmc   +2 more sources

Functionality of beta-adrenergic receptors in patients with cirrhosis treated chronically with non-selective beta-blockers [PDF]

, 2020
Background: In patients with cirrhosis, beta-adrenoceptors expressed on peripheral blood mononuclear cells have a reduced response to catecholamine stimulation.
Almenara, Susana, BELLOT, PABLO, Francés, Rubén, Gimenez, Paula, González-Navajas, Jose Manuel, Herrera, Ivan, Lozano, Beatriz, Miralles, Cayetano, Pascual, Sonia, Rodríguez, María, Zapater, Pedro   +10 more
core   +1 more source

A Comparative Inflammation‐on‐a‐Chip with a Complete 3D Interface: Pharmacological Applications in COPD‐Induced Neutrophil Migration

Advanced Healthcare Materials, Volume 12, Issue 30, December 4, 2023., 2023
A comparative inflammation‐on‐a‐chip (IoC), not having fixed structures such as micropillar and phaseguide structures, is newly developed with two comparative channels. This is the first study to evaluate inhibitors of CXCR2‐dependent neutrophil transendothelial migration (NETM) in this IoC model that mimics the physiological 3D microenvironment ...
Soohyun Kim, Sung Kyun Lee, Ahryeong Son, Jong‐Hwan Lee, Hong Gi Kim   +4 more
wiley   +1 more source

Role of the Intracellular Sodium Homeostasis in Chemotaxis of Activated Murine Neutrophils

Frontiers in Immunology, 2020
The importance of the intracellular Ca2+ concentration ([Ca2+]i) in neutrophil function has been intensely studied. However, the role of the intracellular Na+ concentration ([Na+]i) which is closely linked to the intracellular Ca2+ regulation has been ...
Karolina Najder, Micol Rugi, Micol Rugi, Mégane Lebel, Julia Schröder, Leonie Oster, Sandra Schimmelpfennig, Sarah Sargin, Zoltán Pethő, Etmar Bulk, Albrecht Schwab   +10 more
doaj   +1 more source

[6]‐Gingerol Facilitates CXCL8 Secretion and ROS Production in Primary Human Neutrophils by Targeting the TRPV1 Channel

Molecular Nutrition &Food Research, Volume 67, Issue 4, February 2023., 2023
This study investigates the impact of a pungent compound from ginger, [6]‐gingerol, on the immune responses of a specific human blood leukocyte cell type, the neutrophils. The study observes that [6]‐gingerol facilitates the production of reactive oxygen species and the secretion of a chemokine (CXCL8) upon subsequent stimulation with a bacterial ...
Gaby Andersen, Kristin Kahlenberg, Dietmar Krautwurst, Veronika Somoza   +3 more
wiley   +1 more source

Structural basis for the inhibition of human angiotensin‐1 converting enzyme by fosinoprilat

The FEBS Journal, Volume 289, Issue 21, Page 6659-6671, November 2022., 2022
Analysis of high‐resolution crystal structures of angiotensin I‐converting enzyme (ACE) N‐ and C‐domains in complex with fosinoprilat provide further insights into the requirements for high‐affinity domain‐specific inhibition that is required to reduce side effects of treatments that target ACE.
Gyles E. Cozier, Emma C. Newby, Sylva L. U. Schwager, R. Elwyn Isaac, Edward D. Sturrock, K. Ravi Acharya   +5 more
wiley   +1 more source

Polymorphonuclear Cell Chemotaxis and Suicidal NETosis: Simultaneous Observation Using fMLP, PMA, H7, and Live Cell Imaging

Journal of Immunology Research, 2020
Chemotaxis and the formation of suicidal neutrophil extracellular traps (suicidal NETosis) are key functions of polymorphonuclear cells (PMNs). Neutrophil extracellular traps in particular are known to be significantly involved in the severity of ...
Delou Pai, Michael Gruber, Sophie-Marie Pfaehler, Andre Bredthauer, Karla Lehle, Benedikt Trabold   +5 more
doaj   +1 more source

Less Neutrophil Extracellular Trap Formation in Term Newborns than in Adults [PDF]

, 2016
Background: Newborns are prone to infections, which are independent predictors of neonatal mortality and morbidity. Neutrophil extracellular traps (NETs) are structures composed of chromatin and antimicrobial molecules that capture and kill pathogens ...
Dressel, Alexander, Heckmann, Matthias, Lange, Anja, Lipp, Patrick, Ruhnau, Johanna, Vogelgesang, Antje   +5 more
core   +1 more source

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils

Journal of Leukocyte Biology, Volume 111, Issue 2, Page 367-377, February 2022., 2022
Graphical Abstract First study to report CD200R1L protein expression in humans; CD200R1L induces production of reactive oxygen species and IL‐8. Abstract Inhibitory and activating immune receptors play a key role in modulating the amplitude and duration of immune responses during infection and in maintaining immune balance in homeostatic conditions ...
M. Inês Pascoal Ramos, Can Keşmir, Jorn E. Stok, Ruben Geerdink, Nikolaos Satravelas, Geertje H A Westerlaken, Linde Meyaard, Michiel van der Vlist   +7 more
wiley   +1 more source

Characterization of Circulating Low-Density Neutrophils Intrinsic Properties in Healthy and Asthmatic Horses

Scientific Reports, 2017
Low-density neutrophils (LDNs) are a subset of neutrophils first described in the bloodstream upon pathological conditions, and recently, in the blood of healthy humans.
Nicolas Herteman, Amandine Vargas, Jean-Pierre Lavoie   +2 more
doaj   +1 more source