Results 121 to 130 of about 13,562,347 (304)
Structural flexibility within N-glycan chains.
, 2013 Two examples of N-glycan sequences (A and B) and their GDT chart (C for A and D for B) for the corresponding N-glycan structure pairs in the PDB. Each horizontal bars represents the distance deviation of carbohydrate ring atoms for different N-glycan ...
Sunhwan Jo (79055) +3 more
core +1 more source
Advanced Science, EarlyView.Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu +10 more
wiley +1 more source
Percentages of three types of 146-N-glycan conformations (“-gly” means with glycan).
, 2015 Percentages of three types of 146-N-glycan conformations (“-gly” means with glycan).
Zhonghua Wang (197514) +4 more
core +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
, 2018 Nucleic acid aptamers, as useful alternatives of antibodies, have found a large range of promising applications such as affinity separation and bioassays. The screening of aptamers is critical for their applications.
Wei Li (7081) +7 more
core +1 more source
Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition and adhesion [PDF]
, 2004 Carbohydrates at the cell surface have been proposed as mediators in cell-cell recognition events involved in embryogenesis, metastasis, and other proliferation processes by calcium-dependent carbohydrate to carbohydrate interactions.
Bucior, Iwona
core +1 more source
Advanced Science, EarlyView.A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan +7 more
wiley +1 more source
Advanced Science, EarlyView.Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha +5 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe +8 more
wiley +1 more source
PLoS ONE, 2015 IntroductionSerum N-glycans have been identified as putative biomarkers for numerous diseases. The impact of different serum sample tubes and processing methods on N-glycan analysis has received relatively little attention.
Nicholas T Ventham +9 more
doaj +1 more source