Results 161 to 170 of about 95,722 (299)

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

N-Glycan analysis and engineering

, 2019
The structural elucidation of N-glycans represents an analytical challenge as N-glycans are diverse with more than 100,000 reported structures. N-Glycans are complex molecules, up to 5000 Da in size, and their functions are determined by their unique chemical structures.
openaire   +1 more source

High-Throughput N-Glycan Analysis by IR-MALDESI With a 1.5-kHz Pulsed Mid-IR Laser. [PDF]

J Mass Spectrom
Eisenberg SM, Ashbacher SM, Wainwright AAC, Gu A, Miller RJD, Muddiman DC.   +5 more
europepmc   +1 more source

The Biological Basis and Analyses of N-Glycan Microheterogeneity. [PDF]

Mol Cell Proteomics
Adams TM, Zhao P, Seenivasan SH, Wells L.   +3 more
europepmc   +1 more source

Sequence-Based and Functional Analysis for the Discovery of N-Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut. [PDF]

Microbiologyopen
Boscá-Sánchez I, Rodríguez-Díaz J, Yebra MJ.   +2 more
europepmc   +1 more source

Globo‐H diagnostic stratification and identification of DUSP14 as a candidate target in colorectal cancer

International Journal of Cancer, EarlyView.
What's New? Colorectal cancer (CRC) is increasingly complicated by drug‐resistant tumors that limit the effectiveness of anticancer therapies. Because resistance mechanisms vary among patients and can evolve over time, personalized treatment strategies are needed.
Keren Zohar, Marco Strecker, Thomas Wartmann, Wenjie Shi, Frederike Stelter, Maximilian Doelling, Mihailo Andric, Or Kakhlon, Christian Täger, Denny Schanze, Michael Linnebacher, Michael Naumann, Daniel E. Stange, Dörthe Jechorek, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fucosylated N-Glycan Landscape of Triple-Negative Breast Cancer. [PDF]

Mol Cancer Res
Scott DA, Seal S, Spruill L, Dunne J, Colditz G, Mehta AS, Drake RR, Ford ME, Angel PM.   +8 more
europepmc   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a. [PDF]

Structure
Kremer PG, Tolbert WD, Gazaway E, Hernandez BG, Korzeniowski MK, Dyba ZA, Grelsson T, Grant OC, Lanzilotta WN, Pazgier M, Woods RJ, Barb AW.   +11 more
europepmc   +1 more source