Results 291 to 300 of about 13,066,219 (329)
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2021
Glycosylation, one of the most common post-translational modifications in mammalian cells, impacts many biological processes such as cell adhesion, proliferation and differentiation. As the most abundant glycoprotein in human serum, immunoglobulin G (IgG) plays a vital role in immune response and protection. There is a growing body of evidence suggests
Si, Liu, Xin, Liu
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Glycosylation, one of the most common post-translational modifications in mammalian cells, impacts many biological processes such as cell adhesion, proliferation and differentiation. As the most abundant glycoprotein in human serum, immunoglobulin G (IgG) plays a vital role in immune response and protection. There is a growing body of evidence suggests
Si, Liu, Xin, Liu
openaire +2 more sources
N -glycan and Alzheimer's disease
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Alzheimer's disease (AD) is a major form of dementia. Many evidence-based clinical trials have been performed, but no effective treatment has yet been developed. This suggests that our understanding of AD patho-mechanisms is still insufficient. In particular, the pathological roles of posttranslational modifications including glycosylation have ...
Yasuhiko, Kizuka +2 more
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Analytical Chemistry, 2018
Antibodies specific to glycans are essential in many areas for many important fields, including disease diagnostics, therapeutics, and fundamental researches. However, due to their low immunogenicity and poor availability, glycans pose serious challenges
Zijun Bie +5 more
semanticscholar +1 more source
Antibodies specific to glycans are essential in many areas for many important fields, including disease diagnostics, therapeutics, and fundamental researches. However, due to their low immunogenicity and poor availability, glycans pose serious challenges
Zijun Bie +5 more
semanticscholar +1 more source
Chromatographic Profiling of N-Glycans
2019Most glycoproteins carry a very heterogeneous mixture of oligosaccharides and even a single glycosylation site of a pure glycoprotein is often heterogeneously glycosylated. The structural diversity of oligosaccharides arises from linkage variants, from differences in the size and number of charges of glycans, and from differences in the monosaccharide ...
Martin, Gohlke, Véronique, Blanchard
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Separation of N-Glycans by HPLC
2008Most glycoproteins carry a very heterogeneous mixture of oligosaccharides and even a single glycosylation site of a pure glycoprotein is often heterogeneously glycosylated. The structural diversity of oligosaccharides arises from linkage variants, from differences in the size and number of charges of glycans, and from differences in the monosaccharide ...
Martin, Gohlke, Véronique, Blanchard
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Regulation of integrin functions by N-glycans
Glycoconjugate Journal, 2004Integrins are cell surface transmembrane glycoproteins that function as adhesion receptors in cell-ECM interactions and link matrix proteins to the cytoskeleton. Integrins play an important role in cytoskeleton organization and in the transduction of intracellular signals, regulating various processes such as proliferation, differentiation, apoptosis ...
Jianguo, Gu, Naoyuki, Taniguchi
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N-Glycan processing and glycoprotein folding
2001Publisher Summary This chapter describes how N-glycan processing participates in the folding and quality control mechanisms operating in the ER. Glycosylation of asparagine residues (N-glycosylation) in the endoplasmic reticulum (ER) presents two basic differences with respect to glycosylation of Ser/Thr residues (Ooglycosylation) in either the ...
E S, Trombetta, A J, Parodi
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N-glycans in Toxicodendron vernicifluum lacquer laccase
Carbohydrate Research, 2019The N-glycans in Toxicodendron vernicifluum (Rhus vernicifera) lacquer laccase was elucidated for the first time through a combination of enzymatic digestion and subsequent mass spectrometry measurements using LC-MS/MS and MALDI-TOF MS. Lacquer laccase was isolated from a Japanese lacquer acetone powder from consecutive Sephadex C-50 and DEAE A-50 ...
Oyunjargal Tumurbaatar +4 more
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