Results 31 to 40 of about 13,466,171 (149)

Exploring the Therapeutic Mechanism of Xinbao Pill in Brain Injury After Cardiopulmonary Resuscitation Based on Network Pharmacology, Metabolomics, and Experimental Verification

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
A diagram illustrating a network‐based mechanism exploration framework for XBP against brain injury after cardiopulmonary resuscitation. (A) In vivo and in vitro pharmacodynamic confirmation of XBP against PBI. (B) Network pharmacology approach as well as metabolomics analysis to explore the potential mechanisms.
Dongli Li, Qihui Wu, Zunjiang Li, Baijian Chen, Xing Sun, Qiqi Wu, Zhenzhu Ding, Linling Liu, Jiansong Fang, Ruifeng Zeng, Yong Gu, Banghan Ding   +11 more
wiley   +1 more source

Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants

Plant Biotechnology Journal, Volume 15, Issue 10, Page 1346-1357, October 2017., 2017
Summary Brown planthopper (Nilaparvata lugens Stål, BPH) causes huge economic losses in rice‐growing regions, and new strategies for combating BPH are required. To understand how BPHs respond towards BPH‐resistant plants, we systematically analysed the metabolic differences between BPHs feeding on the resistant and susceptible plants using NMR and GC ...
Caixiang Liu, Ba Du, Fuhua Hao, Hehua Lei, Qianfen Wan, Guangcun He, Yulan Wang, Huiru Tang   +7 more
wiley   +1 more source

Metabolic pathways involving mesaconase reaction: (A) mesaconate utilization, (B) methylaspartate pathway of glutamate fermentation.

, 2015
Enzymes: 1, mesaconase; 2, succinyl-CoA:(S)-citramalate CoA-transferase; 3, (S)-citramalyl-CoA lyase; 4, glutamate mutase; 5, methylaspartate ammonia-lyase; 6, citramalate lyase.
Miriam Kronen (837168), Ivan A. Berg (837169)   +1 more
core   +1 more source

Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids

, 2012
The redesign of enzymes to produce catalysts for a predefined transformation remains a major challenge in protein engineering. Here, we describe the structure-based engineering of methylaspartate ammonia lyase (which in nature catalyses the conversion of
Raj, Hans, Wildeman, Stefaan de, Andy-Mark W. H. Thunnissen, Wim J. Quax, Janssen, Dick B., Ben L. Feringa, Dick B. Janssen, Dekker, Frank J.,, Thunnissen, Andy-Mark W.H., Quax, Wim J.; id_orcid, Quax, Wim J.,, Szymański, Wiktor,, Poelarends, Gerrit J.,, Rozeboom, Henriëtte J.; id_orcid, Thunnissen, Andy-Mark W.H.; id_orcid, Dekker, Frank J., Feringa, Ben L., Wildeman, Stefaan de,, Villiers, Jandré de,, Jandré de Villiers, Gerrit J. Poelarends, Hans Raj, Quax, Wim J., Carlos R. Reis, Villiers, Marianne de, Puthan Veetil, Vinod,, Puthan Veetil, Vinod, Szymanski, Wiktor, Marianne de Villiers, Reis, Carlos R., Reis, Carlos R.,, Thunnissen, Andy-Mark W.H.,, Dekker, Frank J.; id_orcid, Vinod Puthan Veetil, de Villiers, Jandre, Frank J. Dekker, Janssen, Dick B.,, Feringa, Ben L.,, Rozeboom, Henriëtte J., Poelarends, Gerrit J., Poelarends, Gerrit J.; id_orcid, Wiktor Szymański, Raj, Hans,, Henriëtte J. Rozeboom, Stefaan de Wildeman, Rozeboom, Henriëtte J.,, Villiers, Marianne de,   +46 more
core   +1 more source

Nitric oxide delays the postharvest nutritional quality decline of “Golden Hook” beans

Food Frontiers, Volume 5, Issue 2, Page 636-655, March 2024.
NO treatment can enhance the defense ability of “Golden Hook” beans by enhancing the expression of resistance gene and promoting the expression of jasmonic acid defense pathway. NO also induced the biosynthesis of flavonoids and the accumulation of related metabolites by regulating the expression of antioxidant enzyme genes, thus enhancing its ...
Xuelian He, Lihong Wang, Christopher B. Watkins, Chunmei Bai, Lili Ma, Susu Guo, Lichun Han, Hongwei Wang, Qing Wang, Jinhua Zuo, Yanyan Zheng   +10 more
wiley   +1 more source

Malate Synthase and β-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica

, 2017
Haloarchaea are extremely halophilic heterotrophic microorganisms belonging to the class Halobacteria (Euryarchaeota). Almost half of the haloarchaea possesses the genes coding for enzymes of the methylaspartate cycle, a recently discovered anaplerotic ...
Xiang, H., Han, J., Borjian, F., Hou, J., Zarzycki, J., Berg, I.   +5 more
core   +1 more source

Mechanistic studies of the enzyme 3-methylaspartate ammonia-lyase

, 1989
3-Methylaspartate ammonia-lyase (E.C. 4.3.1.2), catalyses the reversible elimination of ammonia from methylaspartic acid. The enzyme from Clostridium tetanomorphum has been purified to homogeneity in three stages using a new method; acetone fractionation
Cohen, Mark Adam
core   +1 more source

Biocatalytic Enantioselective Hydroaminations for Production of N-Cycloalkyl-Substituted L-Aspartic Acids Using Two C-N Lyases [PDF]

, 2019
N‐cycloalkyl‐substituted amino acids have wide‐ranging applications in pharma‐ and nutraceutical fields. Here we report the asymmetric synthesis of various N‐cycloalkyl‐substituted L‐aspartic acids using ethylenediamine‐N,N'‐disuccinic acid lyase (EDDS ...
Tepper, Pieter, Gerrit J. Poelarends, Poelarends, Gerrit, Zhang, Jielin, Fu, Haigen, Poelarends, Gerrit; id_orcid, Haigen Fu, Pieter G. Tepper, Jielin Zhang   +8 more
core   +2 more sources

Research progress of gene target therapy for refractory epilepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Nowadays, the strategies of gene therapy for the treatment of refractory epilepsy (RE) mainly include modulating neurotransmitter systems, neuropeptide Y (NPY) and neurotrophic factors.
Xing-hua TANG, Lin LI, Zhen-guo LIU
doaj  

Interconversion of (S)-Glutamate and (2S,3S)-3-Methylaspartate:  A Distinctive B₁₂-Dependent Carbon-Skeleton Rearrangement

, 2016
The interconversion of (S)-glutamate and (2S,3S)-3-methylaspartate catalyzed by B12-dependent glutamate mutase is discussed using results from high-level ab initio molecular orbital calculations.
Stacey D. Wetmore (696456), Bernard T. Golding (129309), David M. Smith (155808), Leo Radom (1485967)   +3 more
core   +1 more source