Results 1 to 10 of about 94,865 (129)

Human proto-oncogene N-myc encodes nuclear proteins that bind DNA. [PDF]

Molecular and Cellular Biology, 1986
N-myc is a gene whose amplification has been implicated in the genesis of several malignant human tumors. We have identified two proteins with molecular weights of 65,000 and 67,000 encoded by N-myc. The abundance of these proteins in tumor cells was consonant with the extent of amplification of N-myc.
G, Ramsay, L, Stanton, M, Schwab, J M, Bishop   +3 more
  +5 more sources

N-Myc Proto-Oncogene Protein [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Molecular Mechanisms of MYCN Dysregulation in Cancers

Frontiers in Oncology, 2021
MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma
Ruochen Liu, Ruochen Liu, Ruochen Liu, Pengfei Shi, Pengfei Shi, Pengfei Shi, Zhongze Wang, Zhongze Wang, Chaoyu Yuan, Chaoyu Yuan, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +12 more
doaj   +1 more source

Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

Frontiers in Cell and Developmental Biology, 2021
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver.
Longchang Bai, Longchang Bai, Longchang Bai, Yingkang Ma, Yingkang Ma, Yingkang Ma, Xue Wang, Qiongni Feng, Qiongni Feng, Zhining Zhang, Zhining Zhang, Zhining Zhang, Sijie Wang, Sijie Wang, Sijie Wang, Huijie Zhang, Huijie Zhang, Huijie Zhang, Xinyu Lu, Xinyu Lu, Xinyu Lu, Yonghui Xu, Erhu Zhao, Erhu Zhao, Erhu Zhao, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +28 more
doaj   +1 more source

Excellent treatment outcomes in children younger than 18 months with stage 4 nonamplified neuroblastoma [PDF]

Korean Journal of Pediatrics, 2018
PurposeAlthough the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen.
Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo   +5 more
doaj   +1 more source

Alternative approaches to target Myc for cancer treatment

Signal Transduction and Targeted Therapy, 2021
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively.
Chen Wang, Jiawei Zhang, Jie Yin, Yichao Gan, Senlin Xu, Ying Gu, Wendong Huang   +6 more
doaj   +1 more source

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Cells, 2023
The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance.
Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher, Monica L. Fernández-Quintero, Kathrin Breuker, Celina E. Juliano, Klaus R. Liedl, Bert Hobmayer, Markus Hartl   +9 more
doaj   +1 more source

c-Myc Alters Substrate Utilization and O-GlcNAc Protein Posttranslational Modifications without Altering Cardiac Function during Early Aortic Constriction. [PDF]

PLoS ONE, 2015
Hypertrophic stimuli cause transcription of the proto-oncogene c-Myc (Myc). Prior work showed that myocardial knockout of c-Myc (Myc) attenuated hypertrophy and decreased expression of metabolic genes after aortic constriction.
Dolena Ledee, Lincoln Smith, Margaret Bruce, Masaki Kajimoto, Nancy Isern, Michael A Portman, Aaron K Olson   +6 more
doaj   +1 more source

Transcriptome analysis of blastoderms exposed to prolonged egg storage and short periods of incubation during egg storage

BMC Genomics, 2022
Background Cool temperature egg storage prior to incubation is a common practice in the broiler industry; however, prolonged egg storage causes increased embryonic mortality and decreased hatchability and growth in surviving chicks.
K. Brady, C. C. Talbot, J. A. Long, G. Welch, N. French, D. Nicholson, M. R. Bakst   +6 more
doaj   +1 more source

Molecular Changes in Tissue Proteome during Prostate Cancer Development: Proof-of-Principle Investigation

Diagnostics, 2020
(1) Background: Prostate cancer (PCa) is characterized by high heterogeneity. The aim of this study was to investigate molecular alterations underlying PCa development based on proteomics data.
Agnieszka Latosinska, Katarina Davalieva, Manousos Makridakis, William Mullen, Joost P. Schanstra, Antonia Vlahou, Harald Mischak, Maria Frantzi   +7 more
doaj   +1 more source