Results 151 to 160 of about 16,483,910 (214)

Sustained MYC overexpression drives myeloid differentiation block and acquisition of leukemic phenotypes. [PDF]

Exp Hematol
Stokes N, Carcamo S, Demircioglu D, Wang X, Olszewska M, Hasson D, Watanabe H, Papapetrou EP, Dominguez-Sola D.   +8 more
europepmc   +1 more source

From EGFR PTM network to TKI resistance: spatial subtypes and targeting in lung cancer. [PDF]

Cancer Drug Resist
Lai B, Xu C, Lai S, Zhou M, Kong H, Kong E, Yahaya BH.   +6 more
europepmc   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

Enzymatically Hydrolyzed Eggshell Membrane Promotes Keratinocyte Differentiation Associated With PKC and Akt Signaling Pathways. [PDF]

J Food Sci
Furukawa K, Ando C, Kataoka T, Hasebe Y, Kato H, Jia H.   +5 more
europepmc   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, EarlyView.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Changes in the transcriptome and synthetic lethal dependencies following <i>KRAS</i> mutant expression reveal profound tissue specificity. [PDF]

Proc Natl Acad Sci U S A
Martin TD, Choi MY, McBride JC, Elledge SJ.   +3 more
europepmc   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

KRAS and MYC synergistic inhibition: a powerful strategy targeting KRAS-mutant cancers. [PDF]

Mol Cancer
Yan M, Liu K, Xu J, Liu Y, Ji L, Zhang S.   +5 more
europepmc   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Fat Mass and Obesity-Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B-Cell Lymphoma by Suppressing N6-Methyladenosine Methylation of Myc. [PDF]

Kaohsiung J Med Sci
Lu TT, Chen JH, Wang YF, Wu X, Ni HY, Zhang QR.   +5 more
europepmc   +1 more source