Results 1 to 10 of about 20,887 (223)

CCNB1IP1 prevents ubiquitination‐mediated destabilization of MYCN and potentiates tumourigenesis of MYCN‐amplificated neuroblastoma

Clinical and Translational Medicine, 2023
Background MYCN amplification as a common genetic alteration that correlates with a poor prognosis for neuroblastoma (NB) patients. However, given the challenge of directly targeting MYCN, indirect strategies to modulate MYCN by interfering with its ...
Yang Zhou, Hui Yan, Qiang Zhou, Penggao Wang, Fang Yang, Ziqiao Yuan, Qianming Du, Bo Zhai   +7 more
doaj   +2 more sources

MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway [PDF]

Cell Death Discovery
Neuroblastoma is a rare childhood cancer in which high-risk disease, frequently driven by MYCN amplification, has poor survival. Trk-receptor expression correlates with prognosis: TrkA is observed in low-risk cases while TrkB is often expressed in high ...
Stephanie Maher, Andrew Roe, Kieran Wynne, Vadim Zhernovkov, Melinda Halasz   +4 more
doaj   +2 more sources

DMAMCL induces ferroptosis in neuroblastoma by targeting HMOX1 in MYCN-amplified subtypes whereas targeting STEAP3 in MYCN-nonamplified subtypes [PDF]

Redox Report
Objectives Neuroblastoma (NB) is a common pediatric extracranial solid tumor. Dimethylaminomicheliolide (DMAMCL), a prodrug of Micheliolide (MCL), shows antitumor activity against NB, but its mechanisms remain unclear.
Yifan Ma, Simeng Zhang, Dongyang Zhang, Zhongyan Hua, Zhijie Li   +4 more
doaj   +2 more sources

MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia

Epigenetics, 2022
Ten-Eleven-Translocation 5-methylcytosine dioxygenases 1–3 (TET1-3) convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), using oxygen as a co-substrate.
Anastasia E. Hains, Sakshi Uppal, John Z. Cao, Helen R. Salwen, Mark A. Applebaum, Susan L. Cohn, Lucy A. Godley   +6 more
doaj   +1 more source

MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma

Frontiers in Oncology, 2022
Amplification of the MYCN gene leads to its overexpression at both the mRNA and protein levels. Overexpression of MYCN mRNA may also have an important role in promoting neuroblastoma (NB) beyond the translation of MYCN protein.
Tao Liu, Lubing Gu, Zhongzhi Wu, Najah Albadari, Wei Li, Muxiang Zhou   +5 more
doaj   +1 more source

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice

Stem Cell Research & Therapy, 2022
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang, Ruihuan Yang, Ruyi Li, Yining Zuo, Fan Gu, Miao He, Zhuan Bian   +6 more
doaj   +1 more source

Enhancer of zeste homolog 2 regulates cell differentiation and proliferation in neuroblastoma

Universa Medicina, 2014
BACKGROUND Neuroblastoma  (NB)  is  one  of  the  most  common  extracranial  solid  tumors occurring in infancy and childhood with highly variable outcomes. Polycomb group (PcG) proteins are epigenetic gene silencers.
Amallia N. Setyawati, Takehiko Kamijo
doaj   +1 more source

Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. [PDF]

PLoS ONE, 2009
BACKGROUND:Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths.
Derek M Murphy, Patrick G Buckley, Kenneth Bryan, Sudipto Das, Leah Alcock, Niamh H Foley, Suzanne Prenter, Isabella Bray, Karen M Watters, Desmond Higgins, Raymond L Stallings   +10 more
doaj   +1 more source

Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma

Molecular Oncology, 2020
Detection of amplification of the MYCN gene is essential for determining optimal treatment and estimating prognosis of patients with neuroblastoma (NB).
Yan Su, Lijun Wang, Qian Zhao, Zhixia Yue, Wen Zhao, Xisi Wang, Chao Duan, Mei Jin, Dawei Zhang, Shenglan Chen, Jianfeng Yin, Lihua Qiu, Xianfeng Cheng, Zhong Xu, Xiaoli Ma   +14 more
doaj   +1 more source

Molecular Heterogeneity in Neuroblastoma and Its Clinical Significance

Journal of Behçet Uz Children's Hospital, 2023
Objective: Tumor heterogeneity describes the differences between cancer cells in the same tumor sample. Neuroblastoma (NB) is a type of cancer where tumor heterogeneity complicates its treatment.
Tekincan Çağrı Aktaş, Safiye Aktaş, Efe Özgür Serinan, Pınar Erçetin, Melek Aydın, Özde Elif Gökbayrak, Aylin Erol, Zekiye Altun, Nur Olgun   +8 more
doaj   +1 more source