Results 1 to 10 of about 15,908 (119)

DMAMCL induces ferroptosis in neuroblastoma by targeting HMOX1 in MYCN-amplified subtypes whereas targeting STEAP3 in MYCN-nonamplified subtypes [PDF]

Redox Report
Objectives Neuroblastoma (NB) is a common pediatric extracranial solid tumor. Dimethylaminomicheliolide (DMAMCL), a prodrug of Micheliolide (MCL), shows antitumor activity against NB, but its mechanisms remain unclear.
Yifan Ma, Simeng Zhang, Dongyang Zhang, Zhongyan Hua, Zhijie Li   +4 more
doaj   +2 more sources

MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia

Epigenetics, 2022
Ten-Eleven-Translocation 5-methylcytosine dioxygenases 1–3 (TET1-3) convert 5-methylcytosine to 5-hydroxymethylcytosine (5-hmC), using oxygen as a co-substrate.
Anastasia E. Hains, Sakshi Uppal, John Z. Cao, Helen R. Salwen, Mark A. Applebaum, Susan L. Cohn, Lucy A. Godley   +6 more
doaj   +1 more source

Molecular Heterogeneity in Neuroblastoma and Its Clinical Significance

Journal of Behçet Uz Children's Hospital, 2023
Objective: Tumor heterogeneity describes the differences between cancer cells in the same tumor sample. Neuroblastoma (NB) is a type of cancer where tumor heterogeneity complicates its treatment.
Tekincan Çağrı Aktaş, Safiye Aktaş, Efe Özgür Serinan, Pınar Erçetin, Melek Aydın, Özde Elif Gökbayrak, Aylin Erol, Zekiye Altun, Nur Olgun   +8 more
doaj   +1 more source

Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Krüppel-like Factor 4 (Klf4) in mice

Stem Cell Research & Therapy, 2022
Background Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene
Zhuo Huang, Ruihuan Yang, Ruyi Li, Yining Zuo, Fan Gu, Miao He, Zhuan Bian   +6 more
doaj   +1 more source

MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma

Frontiers in Oncology, 2022
Amplification of the MYCN gene leads to its overexpression at both the mRNA and protein levels. Overexpression of MYCN mRNA may also have an important role in promoting neuroblastoma (NB) beyond the translation of MYCN protein.
Tao Liu, Lubing Gu, Zhongzhi Wu, Najah Albadari, Wei Li, Muxiang Zhou   +5 more
doaj   +1 more source

Enhancer of zeste homolog 2 regulates cell differentiation and proliferation in neuroblastoma

Universa Medicina, 2014
BACKGROUND Neuroblastoma  (NB)  is  one  of  the  most  common  extracranial  solid  tumors occurring in infancy and childhood with highly variable outcomes. Polycomb group (PcG) proteins are epigenetic gene silencers.
Amallia N. Setyawati, Takehiko Kamijo
doaj   +1 more source

Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma

Molecular Oncology, 2020
Detection of amplification of the MYCN gene is essential for determining optimal treatment and estimating prognosis of patients with neuroblastoma (NB).
Yan Su, Lijun Wang, Qian Zhao, Zhixia Yue, Wen Zhao, Xisi Wang, Chao Duan, Mei Jin, Dawei Zhang, Shenglan Chen, Jianfeng Yin, Lihua Qiu, Xianfeng Cheng, Zhong Xu, Xiaoli Ma   +14 more
doaj   +1 more source

Opportunities and challenges of circulating biomarkers in neuroblastoma [PDF]

Open Biology, 2019
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis
Ricky M. Trigg, Jacqui A. Shaw, Suzanne D. Turner   +2 more
doaj   +1 more source

Upstream ORF affects MYCN translation depending on exon 1b alternative splicing

BMC Cancer, 2009
Background The MYCN gene is transcribed into two major mRNAs: one full-length (MYCN) and one exon 1b-spliced (MYCNΔ1b) mRNA. But nothing is known about their respective ability to translate the MYCN protein.
Tutrone Giovani, Bertrand Christophe, Furhman Lydie, Delloye-Bourgeois Céline, Locher Clara, Valsesia-Wittmann Sandrine, Besançon Roger, Jallas Anne-Catherine, Garin Elisabeth, Puisieux Alain   +9 more
doaj   +1 more source

CCNB1IP1 prevents ubiquitination‐mediated destabilization of MYCN and potentiates tumourigenesis of MYCN‐amplificated neuroblastoma

Clinical and Translational Medicine, 2023
Background MYCN amplification as a common genetic alteration that correlates with a poor prognosis for neuroblastoma (NB) patients. However, given the challenge of directly targeting MYCN, indirect strategies to modulate MYCN by interfering with its ...
Yang Zhou, Hui Yan, Qiang Zhou, Penggao Wang, Fang Yang, Ziqiao Yuan, Qianming Du, Bo Zhai   +7 more
doaj   +1 more source