Results 41 to 50 of about 20,887 (223)
Identifizierung von MYCN als Suppressor des NOTCH-Signalwegs im MYCN-amplifizierten Neuroblastom
, 2023 Das Neuroblastom (NB) ist der häufigste extrakranielle solide Tumor bei Kindern und weist je nach Tumor-Ätiologie ein breites Spektrum an klinischen Symptomen und Heterogenität auf.
Glowacka, Aleksandra
core +2 more sources
MYCN in Neuroblastoma: “Old Wine into New Wineskins”
Diseases, 2021 MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent ...
Maria Braoudaki +3 more
doaj +1 more source
MYCN gene amplification in rhabdomyosarcoma [PDF]
Cancer, 1994 Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
D, Driman +4 more
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Frontiers in Genetics, 2019 As a transcription factor, MYCN regulates myriad target genes including the histone chaperone FACT. Moreover, FACT and MYCN expression form a forward feedback loop in neuroblastoma.
Xinjie Hu +15 more
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There's a Time and a Place for MYCN [PDF]
Cancer Cell, 2012 Brain tumors display extensive diversity. In this issue of Cancer Cell, Swartling et al. provide evidence that the temporal and spatial transcriptional programs in neural stem cells underlie a diverse response to the MYCN oncogene, potentially contributing to cancer diversity.
Phoenix, Timothy N. +1 more
openaire +2 more sources
Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
Cell Death and Disease, 2023 The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration.
Xiaoling Zhang +10 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Although a rare disease, neuroblastoma accounts for the highest proportion of childhood cancer deaths. There is a lack of recurrent somatic mutations in neuroblastoma embryonal tumours, suggesting a possible role for epigenetic alterations in driving ...
Aleksandar Krstic +12 more
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Frontiers in Bioscience-LandmarkBackground: Neuroblastoma (NB), a transcriptionally driven pediatric malignancy, exhibits a remarkable clinical and biological heterogeneity.
Sofya S. Pogodaeva +5 more
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Drugging the Undruggable: Inhibiting MYCN Signalling
Proceedings, 2019 Neuroblastoma is the most common solid malignancy in early. [...]
Jessica K. Holien +3 more
doaj +1 more source
MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma
Frontiers in Oncology, 2021 A wide range of malignancies presents MYCN amplification (MNA) or dysregulation. MYCN is associated with poor prognosis and its over-expression leads to several dysregulations including metabolic reprogramming, mitochondria alteration, and cancer stem ...
Salvatore Raieli +9 more
doaj +1 more source