Results 41 to 50 of about 27,758 (263)

Targeting of the MYCN protein with small molecule c-MYC inhibitors [PDF]

, 2014
This study was funded by grants from the Swedish Research Council and the Swedish Cancer Society. IM and HZ were recipients of graduate student grants from KI (KID), MAH was recipient of a Senior Investigator Award from the Swedish Cancer Society, and ...
Edward V Prochownik, Inga Müller, Oliynyk, G, Ganna Oliynyk (568258), Zirath Hanna, Prochownik Edward V., Larsson, Karin, Anna Frenzel, Marie Arsenian Henriksson, Anna Frenzel (194997), Edward V. Prochownik (163628), Henriksson, MA, Westwood Nicholas J., Oliynyk, Ganna, Hanna Zirath, Marie Arsenian Henriksson (195006), Oliynyk Ganna, Ganna Oliynyk, Larsson, K, Frenzel, A, Frenzel, Anna, Zirath, Hanna, Prochownik, Edward V., Nicholas J Westwood, Frenzel Anna, Zirath, H, Henriksson Marie Arsenian, Karin Larsson, Muller, Inga, Nicholas J. Westwood, Inga Müller (568256), Nicholas J. Westwood (254891), Edward V. Prochownik, Müller, I, Westwood, NJ, Müller Inga, Henriksson, Marie Arsenian, Karin Larsson (568257), Hanna Zirath (195000), Prochownik, EV, Westwood, Nicholas J., Larsson Karin, Oliynyk, G,, Larsson, K,, Westwood, Nicholas J.; id_orcid   +44 more
core   +2 more sources

MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment

Cancers, 2022
Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in children. While many advances have been made in the last few decades to improve patients’ outcome, high-risk neuroblastoma (HR-NB) still shows a very aggressive pattern ...
Damiano Bartolucci, L. Montemurro, S. Raieli, S. Lampis, A. Pession, P. Hrelia, R. Tonelli   +6 more
semanticscholar   +1 more source

The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells

BMC Cancer, 2018
Background MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosarcomas and neuroblastomas.
Eleanor M. O’Brien, Joanna L. Selfe, Ana Sofia Martins, Zoë S. Walters, Janet M. Shipley   +4 more
doaj   +1 more source

Ceftriaxone exerts antitumor effects in MYCN‐driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression

Molecular Oncology, 2023
MYCN proto‐oncogene, bHLH transcription factor (MYCN) amplification is associated with aggressive retinoblastoma (RB) and neuroblastoma (NB) cancer recurrence that is resistant to chemotherapies.
Pamorn Chittavanich, D. Saengwimol, S. Roytrakul, Duangnate Rojanaporn, V. Chaitankar, A. Srimongkol, U. Anurathapan, S. Hongeng, R. Kaewkhaw   +8 more
semanticscholar   +1 more source

AOSNP-ADAPTR resource level-based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors. [PDF]

Brain Pathol
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Sarkar C, Al-Hussaini M, Santosh V, Suri V, Park SH, Piao YS, Tihan T, Ng HK, Buckland M, Jalali R, Kanemura Y, Wesseling P, Komori T.   +12 more
europepmc   +2 more sources

The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells

Journal of Biological Chemistry, 2023
Neuroblastoma (NB) is one of the most common extracranial solid tumors in children. MYCN gene amplification is highly associated with poor prognosis in high-risk NB patients. In non-MYCN-amplified high-risk NB patients, the expression of c-MYC (MYCC) and
Jun-Jun Li, Jin Peng, Ling-Yuan Wu, Xiang Shen, Xinghua Zhen, Yi-Mao Zhang, H. Ma, Yongfeng Xu, Qunli Xiong, Qing Zhu, Pu-Min Zhang   +10 more
semanticscholar   +1 more source

MYCN-DNA-Vakzine zur Behandlung des Neuroblastoms [PDF]

, 2014
Das Neuroblastom (NB) zählt zu den therapieresistentesten Tumoren des Kleinkindalters. Besonders NB-Patienten mit MYCN-Amplifikation sind mit einer schlechten Prognose konfrontiert.
Stermann, Alexander
core   +1 more source

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification [PDF]

Proceedings of the National Academy of Sciences, 2012
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN
Valentijn, Linda J., Koster, Jan, Haneveld, Franciska, Aissa, Rachida Ait, van Sluis, Peter, Broekmans, Marloes E. C., Molenaar, Jan J., van Nes, Johan, Versteeg, Rogier   +8 more
openaire   +3 more sources

An E2F5-TFDP1-BRG1 Complex Mediates Transcriptional Activation of MYCN in Hepatocytes

Frontiers in Cell and Developmental Biology, 2021
Liver regeneration is characterized by cell cycle reentrance of hepatocytes. N-Myc, encoded by MYCN, is a member of the Myc family of transcription factors.
Zhiwen Fan, Zhiwen Fan, Ming Kong, Xiulian Miao, Yan Guo, Haozhen Ren, Haozhen Ren, Jinglin Wang, Jinglin Wang, Shuai Wang, Shuai Wang, Ning Tang, Ning Tang, Longcheng Shang, Zhengyi Zhu, Hanyi Liu, Wei Zhu, Xiaolei Shi, Xiaolei Shi   +18 more
doaj   +1 more source

Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma

Nature Cancer, 2021
Amplification of MYCN is the driving oncogenic change in a subset of high-risk neuroblastomas. The MYCN protein and the Aurora-A kinase form a complex during the S phase that stabilizes MYCN.
Isabelle Roeschert, E. Poon, A. Henssen, H. García, Marco Gatti, Celeste Giansanti, Y. Jamin, C. Ade, P. Gallant, Christina Schülein-Völk, Petra Beli, M. Richards, M. Rosenfeldt, M. Altmeyer, John Anderson, A. Eggert, M. Dobbelstein, R. Bayliss, L. Chesler, G. Büchel, M. Eilers   +20 more
semanticscholar   +1 more source