Results 51 to 60 of about 27,758 (263)
Science Advances, 2022 High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers
C. Nunes +41 more
semanticscholar +1 more source
p53 is a direct transcriptional target of MYCN in neuroblastoma
MYCN amplification occurs in approximately 25% of neuroblastomas, where it is associated with rapid tumor progression and poor prognosis. MYCN plays a paradoxical role in driving cellular proliferation and inducing apoptosis.
Tweddle DA +7 more
core +5 more sources
Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. [PDF]
PLoS ONE, 2009 BACKGROUND:Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths.
Derek M Murphy +10 more
doaj +1 more source
MYCN-targeting vaccines and immunotherapeutics [PDF]
Human Vaccines & Immunotherapeutics, 2016 Amplification and concomitant overexpression of the MYCN oncogene is a frequent event in many malignancies including the childhood tumors, neuroblastoma and medulloblastoma. MYCN is only expressed in a defined time frame during early developmental processes, (1) which is beneficial for approaches combatting tumor-specific MYCN.
Schramm, Alexander, Lode, Holger
openaire +3 more sources
EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma
Cancer Discovery, 2021 Gene expression is regulated by promoters and enhancers marked by histone H3-lysine-27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HATs), EP300 and CBP.
A. Durbin +28 more
semanticscholar +1 more source
Adult Pulmonary Blastoma: A Case Report with Spectrum of Rare Manifestations [PDF]
Türk Patoloji DergisiPulmonary blastoma (PB) is an exceedingly rare and aggressive malignant lung neoplasm that has distinct biphasic morphology. In this report, we document rare manifestations and molecular alterations in PB.
Mayur PARKHI +6 more
doaj +1 more source
MYCN in Neuroblastoma: “Old Wine into New Wineskins”
Diseases, 2021 MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent ...
Maria Braoudaki +3 more
doaj +1 more source
MYCN gene amplification in rhabdomyosarcoma [PDF]
Cancer, 1994 Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
D, Driman +4 more
openaire +2 more sources
Cancer Research, 2021 Effective treatment of pediatric solid tumors has been hampered by the predominance of currently “undruggable” driver transcription factors. Improving outcomes while decreasing the toxicity of treatment necessitates the development of novel agents that ...
Adam J. Wolpaw +24 more
semanticscholar +1 more source