Results 31 to 40 of about 27,758 (263)

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Epigenetic Dysregulation in MYCN-Amplified Neuroblastoma

International Journal of Molecular Sciences, 2023
Neuroblastoma (NB), a childhood cancer arising from the neural crest, poses significant clinical challenges, particularly in cases featuring amplification of the MYCN oncogene.
Soraya Epp, Mei-Chu-Ah Shin, Melinda Halasz   +2 more
semanticscholar   +1 more source

HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype

Cancer Research, 2023
Noradrenergic neuroblastoma (NB) is characterized by a core transcriptional regulatory circuitry (CRC) comprised of transcription factors (TFs) such as PHOX2B, HAND2 and GATA3, which form a network with MYCN.
Man Xu, Ming Sun, Xi-Yuan Zhang, Rosa Nguyen, Hai-Yan Lei, J. Shern, C. Thiele, Zhi-Hui Liu   +7 more
semanticscholar   +1 more source

Correction to "Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup-specific prognostic stratification using economical/accessible diagnostic methods". [PDF]

Brain Pathol
Brain Pathology, EarlyView.
europepmc   +2 more sources

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma

International Journal of Molecular Sciences, 2023
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s ...
P. Agarwal, A. Głowacka, Loay Mahmoud, Wesam Bazzar, L. Larsson, M. Alzrigat   +5 more
semanticscholar   +1 more source

The MYCN Enigma: Significance of MYCN Expression in Neuroblastoma [PDF]

Cancer Research, 2006
Abstract MYCN amplification strongly predicts adverse outcome of neuroblastoma. However, the significance of MYCN expression in the clinical and biological behavior of neuroblastoma has been unclear. To address this question, we first examined the expression of MYCN in combination with TrkA (a favorable prognostic indicator of ...
Xao X, Tang, Huaqing, Zhao, Bing, Kung, David Y, Kim, Sakeenah L, Hicks, Susan L, Cohn, Nai-Kong, Cheung, Robert C, Seeger, Audrey E, Evans, Naohiko, Ikegaki   +9 more
openaire   +2 more sources

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures

Nature Communications, 2023
Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations.
M. Schoof, Shweta Godbole, T. Albert, M. Dottermusch, C. Walter, Annika Ballast, N. Qin, M. Olivera, Carolin Göbel, S. Neyazi, D. Holdhof, C. Kresbach, Levke-Sophie Peter, Gefion Dorothea Epplen, Vanessa Thaden, M. Spohn, Mirjam Blattner-Johnson, F. Modemann, M. Mynarek, S. Rutkowski, M. Sill, J. Varghese, A. Afflerbach, Alicia Eckhardt, Daniel Münter, Archana Verma, N. Struve, David T. W. Jones, M. Remke, J. Neumann, K. Kerl, U. Schüller   +31 more
semanticscholar   +1 more source

The super elongation complex drives transcriptional addiction in MYCN-amplified neuroblastoma

Science Advances, 2023
MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification.
Donghai Wang, Zhi-Nang Yin, Hong-Hong Wang, Liyuan Wang, Tian-Yu Li, Ruijing Xiao, Ting Xie, Ruyi Han, Rui Dong, Hu-Dan Liu, Kai-Wei Liang, G. Qing   +11 more
semanticscholar   +1 more source

MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression

Oncogene, 2023
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression programs. Alternative splicing is another important regulator of gene expression and has been implicated in neuroblastoma development ...
Alice Salib, Nisitha Jayatilleke, Janith A. Seneviratne, C. Mayoh, K. De Preter, Frank Speleman, B. Cheung, Daniel R. Carter, G. M. Marshall   +8 more
semanticscholar   +1 more source

MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis

Cancer Research, 2021
The study shows how MYCN increases intracellular iron levels and subsequent GSH pathway activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in patient-derived xenograft models of MYCN-amplified neuroblastoma.
K. Floros, Jin-Yang Cai, Sheeba Jacob, Richard I. J. Kurupi, Carter K. Fairchild, Mayuri Shende, Colin M. Coon, Krista M. Powell, B. Belvin, Bin Hu, Madhavi Puchalapalli, S. Ramamoorthy, K. Swift, J. Lewis, M. Dozmorov, J. Glod, Jennifer E. Koblinski, S. Boikos, A. Faber   +18 more
semanticscholar   +1 more source