Implementation of the Plasma MYCN/NAGK Ratio to Detect MYCN Amplification in Patients With Neuroblastoma [PDF]
Molecular Oncology, 2020 Detection of amplification of the MYCN gene is essential for determining optimal treatment and estimating prognosis of patients with neuroblastoma (NB).
Qian Zhao, Yan Su, Wang Bo
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Chromosome Band 11q23 Deletion Predicts Poor Prognosis in Bone Marrow Metastatic Neuroblastoma Patients Without MYCN Amplification [PDF]
Cancer Communications, 2019 Background Interphase fluorescence in situ hybridization (FISH) of bone marrow cells has been confirmed to be a direct and valid method to assess the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) amplification in ...
Qian Zhao, Zhixia Yue, Chao Gao
exaly +4 more sources
MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma [PDF]
Cancer Medicine, 2022 Background This study aimed to better understand the prognostic effect of multiple genetic markers and identify more subpopulations at ultra high risk of poor outcome in bone marrow (BM) metastatic neuroblastoma (NB).
Zhi‐Xia Yue +8 more
doaj +2 more sources
MYCN amplification defines an aggressive phenotype in IDH‐mutant gliomas [PDF]
The Journal of Pathology: Clinical ResearchIn alignment with the latest WHO classification system, which underscores the integration of molecular alterations in glioma diagnosis and grading, this study investigates the prognostic significance of MYCN amplification in IDH‐mutant gliomas, a ...
Xujun Xie +5 more
doaj +2 more sources
Predicting MYCN amplification in paediatric neuroblastoma: development and validation of a 18F-FDG PET/CT-based radiomics signature [PDF]
Insights into Imaging, 2023 Objectives To develop and validate an 18F-FDG PET/CT-based clinical-radiological-radiomics nomogram and evaluate its value in the diagnosis of MYCN amplification (MNA) in paediatric neuroblastoma (NB) patients.
Luo-Dan Qian +7 more
doaj +2 more sources
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma [PDF]
Acta Neuropathologica Communications, 2020 We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a unique methylation classifier profile.
Mark Raffeld +12 more
doaj +2 more sources
Radiomics-Based Machine Learning for Determining Amplification Status in Childhood Neuroblastoma: A Systematic Review and Meta-Analysis [PDF]
Technology in Cancer Research & TreatmentIntroduction The MYCN oncogene promotes tumor cell proliferation in neuroblastoma, and its amplification is a well-established marker of poor prognosis. Radiomics-based approaches have shown promise in noninvasively determining MYCN amplification status;
Haoru Wang MD +5 more
doaj +2 more sources
Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples [PDF]
BMC Cancer, 2019 Background MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker.
Dinesh Babu Somasundaram +7 more
doaj +2 more sources
MYCN Amplification Is Associated With Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma [PDF]
International Journal of Molecular Sciences, 2023 Mohammad Alzrigat +2 more
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Association of Heterogeneous MYCN Amplification With Clinical Features, Biological Characteristics and Outcomes in Neuroblastoma: A Report From the Children's Oncology Group [PDF]
European Journal of Cancer, 2020 Hiroyuki Shimada +2 more
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