Results 21 to 30 of about 289,170 (184)

Extracellular Vesicle-Based Method for Detecting MYCN Amplification Status of Pediatric Neuroblastoma. [PDF]

Cancers (Basel), 2022
SIMPLE SUMMARY: MYCN gene amplification, the strongest prognostic marker of aggressive neuroblastoma, is detected on invasive biopsy tissues. This study aimed to establish a less invasive method to detect MYCN status based on MYCN mRNA contents in large ...
Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T, Chareonsirisuthigul T, Phornsarayuth P, Klinkulab N, Jinawath N, Chiangjong W, Anurathapan U, Pattanapanyasat K, Hongeng S, Chutipongtanate S.   +14 more
europepmc   +2 more sources

Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification. [PDF]

Cancers (Basel), 2023
Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for
Talapatra J, Reddy MM.
europepmc   +3 more sources

MYCN amplification and ATRX mutations are incompatible in neuroblastoma. [PDF]

Nat Commun, 2020
Abstract Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor ...
Zeineldin M, Federico S, Chen X, Fan Y, Xu B, Stewart E, Zhou X, Jeon J, Griffiths L, Nguyen R, Norrie J, Easton J, Mulder H, Yergeau D, Liu Y, Wu J, Van Ryn C, Naranjo A, Hogarty MD, Kamiński MM, Valentine M, Pruett-Miller SM, Pappo A, Zhang J, Clay MR, Bahrami A, Vogel P, Lee S, Shelat A, Sarthy JF, Meers MP, George RE, Mardis ER, Wilson RK, Henikoff S, Downing JR, Dyer MA.   +36 more
europepmc   +7 more sources

Therapeutic potential of targeting MYCN: A case series report of neuroblastoma with MYCN amplification. [PDF]

Medicine (Baltimore), 2020
Neuroblastoma (NB) with MYCN amplification has a poor prognosis and high mortality. The potential molecular biological relationship between clinical features and MYCN amplification should be explored.NB patients were examined by fluorescence in situ hybridization (FISH) for MYCN amplification in the tumor mass or bone marrow samples to determine ...
Huang C, Jiang S, Yang J, Liao X, Li Y, Li S.   +5 more
europepmc   +3 more sources

MYCN gene amplification in rhabdomyosarcoma [PDF]

Cancer, 1994
Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer.The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma ...
D, Driman, P S, Thorner, M L, Greenberg, S, Chilton-MacNeill, J, Squire   +4 more
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets

BMC Pediatrics, 2020
Background Neuroblastoma patients with MYCN amplification are associated with poor prognosis. However, the prognostic relevance of MYCN associated genes in neuroblastoma is unclear. Methods The expression profiles of MYCN associated genes were identified
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao   +4 more
doaj   +1 more source

MYCN in Neuroblastoma: “Old Wine into New Wineskins”

Diseases, 2021
MYCN Proto-Oncogene, BHLH Transcription Factor (MYCN) has been one of the most studied genes in neuroblastoma. It is known for its oncogenetic mechanisms, as well as its role in the prognosis of the disease and it is considered one of the prominent ...
Maria Braoudaki, Kyriaki Hatziagapiou, Apostolos Zaravinos, George I. Lambrou   +3 more
doaj   +1 more source

Copy Number Analysis Reveal Genetic Risks of Penile Cancer

Frontiers in Oncology, 2020
ObjectivesTo evaluate copy number alterations (CNAs) in genes associated with penile cancer (PeC) and determine their correlation and prognostic ability with PeC.MethodsWhole-exome sequencing was performed for tumor tissue and matched normal DNA of 35 ...
Yongbo Yu, Chengwen Gao, Chengwen Gao, Yuanbin Chen, Meilan Wang, Jianfeng Zhang, Xiaocheng Ma, Shuaihong Liu, Hang Yuan, Zhiqiang Li, Zhiqiang Li, Haitao Niu   +11 more
doaj   +1 more source

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification [PDF]

Proceedings of the National Academy of Sciences, 2012
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN
Valentijn, Linda J., Koster, Jan, Haneveld, Franciska, Aissa, Rachida Ait, van Sluis, Peter, Broekmans, Marloes E. C., Molenaar, Jan J., van Nes, Johan, Versteeg, Rogier   +8 more
openaire   +3 more sources