Results 41 to 50 of about 272,512 (195)

Copy number gain of MYCN gene is a recurrent genetic aberration and favorable prognostic factor in Chinese pediatric neuroblastoma patients

Diagnostic Pathology, 2013
Background Amplification of MYCN oncogene is an established marker indicating aggressive tumor progression of neuroblastoma (NBL). But copy number analyses of MYCN gene in ganglioneuroblastoma (GNBL) and ganglioneuroma(GN) is poorly described in the ...
Wang Miao, Zhou Chunju, Cai Rongqin, Li Yong, Gong Liping   +4 more
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Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer

Frontiers in Oncology, 2015
The MYCN proto-oncogene is associated with poor outcome across a broad range of pediatric tumors. While amplification of MYCN drives subsets of high risk neuroblastoma and medulloblastoma, dysregulation of MYCN in medulloblastoma (in the absence of ...
Tene Aneka Cage, Yvan eChanthery, Yvan eChanthery, Louis eChesler, Matthew eGrimmer, Matthew eGrimmer, Zachary eKnight, Kevan eShokat, William A Weiss, William A Weiss, William A Weiss, William A Weiss, W. Clay Gustafson, W. Clay Gustafson   +13 more
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MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma

Cell Death and Disease, 2021
MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However,
Yuxiong Lu, Qing Yang, Yubin Su, Yin Ji, Guobang Li, Xianzhi Yang, Liyan Xu, Zhaoliang Lu, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Xiaoqiong Gu, Bo Li   +13 more
doaj   +1 more source

MYCN amplification and 17q in neuroblastoma: Evidence for structural association

MYCN oncogene amplification in neuroblastoma is statistically associated with gain of chromosome segment 17q21-qter. In neuroblastoma cell lines and primary tumors with MYCN amplification in the form of homogeneously staining regions (hsrs ...
O'Neill S; Lastowska M; Ekstrom L; Roberts P; Brodeur GM; Kees UR; Schwab M; Bown N
core   +5 more sources

Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study

Neoplasia: An International Journal for Oncology Research, 2001
To assess the utility of fluorescence in situ hybridization (FISH) for analysis of MYCN gene amplification in neuroblastoma, we compared this assay with Southern blot analysis using tumor specimens collected from 232 patients with presenting ...
Prasad Mathew, Marcus B. Valentine, Laura C. Bowman, Susan T. Rowe, Michael B. Nash, Virginia A. Valentine, Susan L. Cohn, Robert P. Castleberry, Garrett M. Brodeur, A. Thomas Look   +9 more
doaj   +1 more source

Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma

Cell Reports, 2020
Summary: Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL.
Jesus García-López, Kirby Wallace, Joel H. Otero, Rachelle Olsen, Yong-dong Wang, David Finkelstein, Brian L. Gudenas, Jerold E. Rehg, Paul Northcott, Andrew M. Davidoff, Kevin W. Freeman   +10 more
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Bioinformatics analysis of miRNAs in the neuroblastoma 11q-deleted region reveals a role of miR-548l in both 11q-deleted and MYCN amplified tumour cells

Scientific Reports, 2022
Neuroblastoma is a childhood tumour that is responsible for approximately 15% of all childhood cancer deaths. Neuroblastoma tumours with amplification of the oncogene MYCN are aggressive, however, another aggressive subgroup without MYCN amplification ...
Sanja Jurcevic, Simon Keane, Emmy Borgmästars, Zelmina Lubovac-Pilav, Katarina Ejeskär   +4 more
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MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma [PDF]

, 2015
MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this ...
Gherardi, S, Fischer, M, Perini, G, Juraeva, Dilafruz, Norris, Murray D, Marshall, Glenn M, Haber, Michelle, Juraeva, D, Ashton, LJ, Norris, MD ; https://orcid.org/, Marshall, GM, Fletcher, JI ; https://orcid.org/, GHERARDI, SAMUELE, Ashton, Lesley J., Lau, DT, Xue, Chengyuan, Oberthuer, André, PERINI, GIOVANNI, Flemming, CL, Xue, C, Lau, Diana T, Flemming, Claudia L, Fischer, Matthias, Oberthuer, A, Brors, B, Brors, Benedikt, Fletcher, Jamie I, Haber, M ; https://orcid.org/   +27 more
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Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults

Case Reports in Oncological Medicine, 2013
MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms’ tumor, and small cell lung cancer.
Anna Koumarianou, Panagiota Oikonomopoulou, Margarita Baka, Dimitrios Vlachodimitropoulos, Stylianos Argentos, Theodoros Piperos, Maria-Ioanna Christodoulou, Kakoulis Theodoulou, Theodoros Mariolis-Sapsakos   +8 more
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Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

Neoplasia: An International Journal for Oncology Research, 2013
Neuroendocrine prostate cancer (NEPC), also referred to as anaplastic prostate cancer, is a lethal tumor that most commonly arises in late stages of prostate adenocarcinoma (PCA) with predilection to metastasize to visceral organs.
Juan Miguel Mosquera, Himisha Beltran, Kyung Park, Theresa Y. MacDonald, Brian D. Robinson, Scott T. Tagawa, Sven Perner, Tarek A. Bismar, Andreas Erbersdobler, Rajiv Dhir, Joel B. Nelson, David M. Nanus, Mark A. Rubin   +12 more
doaj   +1 more source