Results 181 to 190 of about 19,433,217 (243)

Right ventricular dysfunction in cardiogenic shock on temporary mechanical circulatory support. [PDF]

Eur Heart J Open
Estoppey J, Muresan IM, Bossard M, Leibundgut G, Fahrni G, Blöchlinger S, Ludwig R, Messmer AS, Köchli V, Seiler T, Spahr A, Bernheim AM, Schmidt A, Cuculi F, Hunziker L, Fürholz M.   +15 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Listado de Árbitros. Revista N.33.

Historia y Espacio, 2009
Listado Árbitros
doaj   +1 more source

Beyond Blood Eosinophils: Target-Tier Heterogeneity and Patient Enrichment in COPD Type 2 Inflammation. [PDF]

J Inflamm Res
Zhang J, Zhang P, Zhang Y, Xie Y.
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Clinical and laboratory manifestations and treatment of children with <i>TNFRSF1A</i> gene variants. [PDF]

World J Clin Pediatr
Alexeeva EI, Shingarova MS, Dvoryakovskaya TM, Isaeva KB, Chomakhidze AM, Fetisova AN, Chibisova KV, Krekhova EA, Kriulin IA, Kriulina TY, Tsulukiya IT, Botova MS, Kondratyeva NM, Kokina MY, Makunc AA, Dostiev NA, Savostyanov KV, Pushkov AA, Zhanin IS, Demyanov DS, Kostik MM.   +20 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

All-Oral PI3Kδ and HDAC Inhibition with Parsaclisib Plus Chidamide and Step-Down Maintenance in Relapsed or Refractory Peripheral T-Cell Lymphoma: A Phase Ib Trial. [PDF]

MedComm (2020)
Luo X, Yan Z, Fang W, Duan H, Zhang Q, Wang H, Yao S, Zhang J, Jin Y, Li W, Teng X, Zhang L, Liang L, Lin Q, Wang P, Si H, Miao J, Zhou W, Yao Z, He YW, Xia Q, Liu Y.   +21 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Global Perspectives on Radiotherapy Utilization for Pancreatic Ductal Adenocarcinoma. [PDF]

J Gastrointest Cancer
Reames BN, Miller ED, Zhou Z, Narang A, Quinn PL, White B, Gogineni E, Ejaz A.   +7 more
europepmc   +1 more source