Results 131 to 140 of about 3,497,773 (231)

High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects. [PDF]

Mol Cell
Ryan JJ, Miller KR, Puri A, Sprunger ML, Bochantine MM, Lopez A, Chen S, Bao A, Ling C, Xu A, Bell B, Sohn BS, Li L, Chang C, Mohammed K, Staller MV, Jackrel ME.   +16 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 3, 2022

Semina: Ciências Agrárias, 2022
Semina: Ciênc. Agrár.
doaj  

Associations of cognitive and behavioural impairment in ALS with brain pathology: pTDP-43 versus microglial activation. [PDF]

J Neurol
Slaghekke HMJ, Govaarts R, Mesarosova L, Mühlebner A, Beeldman E, de Visser M, van Es MA, van den Berg LH, van der Kooi AJ, Pijnenburg YAL, Aronica E, Raaphorst J.   +11 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 2, 2022

Semina: Ciências Agrárias, 2022
Semina: Ciênc. Agrár.
doaj  

Sociologie du travail, n° 4, vol. 43, Octobre - Décembre 2001

إنسانيات, 2002
Ammara Bekkouche
doaj   +1 more source

VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. [PDF]

Acta Neuropathol Commun
Tripathi P, Guo H, Yamoah A, Mathur R, Doukas P, Dreser A, Jesse CM, Aronica E, Hermann A, Steinbusch H, Brook GA, Weis J, Goswami A.   +12 more
europepmc   +1 more source

Lancement d'Ariadne n° 43

URFIST Info, 2005
openaire   +2 more sources