Results 151 to 160 of about 14,888,422 (277)

TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sclerosis. [PDF]

Acta Neuropathol
Barone C, Wang R, Cooke S, Ng HP, Ferreira RS, Miranda HC, Qi X.   +6 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration. [PDF]

Nat Neurosci
Liu Y, Huang Z, Hsu YW, Deme P, Frankenfield AM, Wu S, Zhao X, Liu H, Zhang T, Alexander EJ, Liu M, Zhang Y, Wang H, Zhou Y, Monteiro MJ, Hao L, Haughey NJ, Wang J.   +17 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Social determinants of health and outcome of extremely preterm infants: A Swiss population-based study. [PDF]

PLoS One
Decaillet M, Hasenauer T, Schneider J, Bickle Graz M.   +3 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Enhancer RNA-mediated transcriptional regulation of TDP-43 during early neural lineage specification. [PDF]

Anim Cells Syst (Seoul)
Jang Y, Lee H, Oh M, Moon J, Kim SJ, Han J, Park JL, Kim SK.   +7 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 3, 2022

Semina: Ciências Agrárias, 2022
Semina: Ciênc. Agrár.
doaj  

A neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of PKN1. [PDF]

Nat Commun
Yang M, Wang Q, Yan R, Kang D, Luo W, Zhang L, Liu R, Wu L, Gu J, Wang X.   +9 more
europepmc   +1 more source