Results 181 to 190 of about 3,747,620 (278)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS. [PDF]

Acta Neuropathol Commun
Tripathi P, Guo H, Yamoah A, Mathur R, Doukas P, Dreser A, Jesse CM, Aronica E, Hermann A, Steinbusch H, Brook GA, Weis J, Goswami A.   +12 more
europepmc   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 3, 2022

Semina: Ciências Agrárias, 2022
Semina: Ciênc. Agrár.
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Glutaredoxin-1 attenuates transactive response DNA-binding protein 43-induced neurotoxicity by suppressing oxidative stress and transactive response DNA-binding protein 43 aggregation. [PDF]

Neuroreport
Lee JM, Bok E, Kim SR, Kim J.
europepmc   +1 more source

Lancement d'Ariadne n° 43

URFIST Info, 2005
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Patterns in Attribute Selection and Development Reporting in Patient Preference Studies Between 2007-2024: A Systematic Literature Review. [PDF]

J Health Econ Outcomes Res
Lo SH, Hall R, Wong J, Chua GN.
europepmc   +1 more source

Semina: Ciênc. Agrár. Londrina, v. 43, n. 2, 2022

Semina: Ciências Agrárias, 2022
Semina: Ciênc. Agrár.
doaj  

Sociologie du travail, n° 4, vol. 43, Octobre - Décembre 2001

إنسانيات, 2002
Ammara Bekkouche
doaj   +1 more source