Results 31 to 40 of about 2,965,078 (287)
This introduction sketches out what relevance wood and wood products have had in Europe’s industrial societies. It also summarizes some peculiarities of the wood-based businesses caused by both the materiality of wood and the ecologies of forests.
Bemmann Martin
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Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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By considering the expansion of the timber trade in southeast Europe as a resource frontier, this article explores the relationships between the transformation of the technical and material conditions of forest exploitation and the development of its ...
Daheur Jawad
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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The article discusses the advancement of timber traders and former middlemen in Riga’s timber trade during the second half of the 19th and early 20th century.
Wezel Katja
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Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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Introduction: The Economics of Lordship in Late Medieval and Early Modern Europe
This special issue focuses on the economics of lordship in pre-industrial Europe. In the introduction, we start by briefly defining lordship, focusing on both the economic power lords had to demand rents from their tenants and the political power lords ...
Gibbs Spike, Skambraks Tanja
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Chimera states in systems of superdiffusively coupled neurons [PDF]
Background and Objectives: One of the most intriguing collective phenomena, which arise in systems of coupled oscillators of different nature, are chimera states.
Fateev, Ilya Sergeevich +1 more
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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