Results 111 to 120 of about 15,742,091 (291)

Les Temps modernes, janvier 83, n° 438

, 1983
Les Temps modernes, janvier 83, n° 438. In: Les Cahiers du GRIF, n°26, 1983. Jouir. pp.

core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Raison présente, n° 83, 3e trim. 1987

, 1987
Raison présente, n° 83, 3e trim. 1987. In: L'Homme et la société, N. 84, 1987. Éthique et science sociale. pp.

core  

Group characteristics of the ADHD group (N = 83) and TD group (N = 72).

, 2016
Group characteristics of the ADHD group (N = 83) and TD group (N = 72).
Henk J. Blom (284315), Jaap Oosterlaan (279272), Catharina Elisabeth Bergwerff (2553037), Marjolein Luman (2553034)   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improving the efficiency of spine region segmentation using an ensemble of pre-trained neural networks

Біофізичний вісник
Background: The accuracy of segmentation of vertebrae in X-ray images is critical for clinical decisions as the manual method is laborious. The use of deep learning is complicated by low contrast, noise, and patient position artifacts.
V. D. Koniukhov, O. M. Morgun, К. Е. Nemchenko   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Resolução Administrativa n. 2879, de 9 de março de 2026

Referenda o Ato n. 83/SEGJUD.GP, de 12 de fevereiro de 2026, que dispõe sobre a remoção da Exma. Sra. Ministra MARIA HELENA MALLMANN da Subseção I para a Subseção II da Seção Especializada em Dissídios Individuais do Tribunal Superior do ...
Brasil. Tribunal Superior do Trabalho (TST)
core   +1 more source

A linear programming-based matheuristic for reliable customer–feeder mapping in smart grids

Energy Reports
Electric power distribution companies are highly concerned about their lack of knowledge about the distribution network maps used to give service to their customers. When dealing with three-phase networks, phase mapping is important to efficiently manage
Aitziber Unzueta, M. Araceli Garín, Juan I. Modroño, Larraitz Aranburu   +3 more
doaj   +1 more source