Results 141 to 150 of about 1,792,273 (291)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Resolução n. 83, de 23 de agosto de 2011 [PDF]

, 2011
Altera dispositivos da Resolução n. 63, de 28 de maio de 2010, que institui a padronização da estrutura organizacional e de pessoal dos órgãos da Justiça do Trabalho de primeiro e segundo graus.Determina a republicação da Resolução n.
Conselho Superior da Justiça do Trabalho (Brasil) (CSJT)
core  

Boletín Diario Oceanográfico vol.5 N°83, 2018

, 2022
Reporta información diaria relacionada a las temperaturas y anomalías del nivel de superficie del ambiente marino y lacustre del Perú, en base a registros in situ y de percepción remota, con el propósito de monitorear las condiciones térmicas asociadas a los efectos de la variabilidad climática y del ciclo ENOS.
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Yrast states of neutron-rich N=83 nuclei from fissionproduct gamma-ray studies [PDF]

, 1997
Prompt gamma-ray cascades in N=83 fission product nuclei near Sn-132 have been studied at Eurogam II using a Cm-248 source. Cross coincidences observed between gamma rays from complementary light and heavy fission fragments were vital for isotopic ...
Lubkiewicz, E, Leddy, M.J., Blomqvist, J, Daly, P J, Schulz, N., Lubkiewicz, E., Smith, A G; id_orcid, Morss, L R, Durell, J L, Urban, W., Durell, J.L., Phillips, W.R., Daly, P.J., Ahmad, I., Lauritsen, T., Blomqvist, J., Zhang, C.T., Grabowski, Z.W., Fornal, B, Bhattacharyya, P., Morss, L.R., Smith, A.G., Phillips, W R, Zhang, C T, Grabowski, Z W, Leddy, M J, Bentaleb, M, Fornal, B., Schulz, N, Varley, B J, Varley, B.J., Ahmad, I, Bentaleb, M., Lauritsen, T, Bhattacharyya, P, Urban, W   +35 more
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Boletín Diario Oceanográfico vol.1 N°83, 2014

, 2022
Reporta información diaria relacionada a las temperaturas y anomalías del nivel de superficie del ambiente marino y lacustre del Perú, en base a registros in situ y de percepción remota, con el propósito de monitorear las condiciones térmicas asociadas a los efectos de la variabilidad climática y del ciclo ENOS.
openaire   +2 more sources