Results 21 to 30 of about 471 (105)

The Causal Role of Adiposity in Mental Illness: A Systematic Review and Meta‐Analysis of Mendelian Randomization Studies

Obesity Reviews, EarlyView.
ABSTRACT Objective This study aimed to examine the causal effect of adiposity on mental illnesses by summarizing and assessing evidence from Mendelian randomization (MR) studies. Method Searches were conducted on Embase, Medline, and Web of Science from database inception to September 22nd, 2025.
Min Gao, Paul J. Doody, Dimitrios A. Koutoukidis, Yebo Yu, Paul Aveyard, Richard Stevens, Padraig C. Dixon   +6 more
wiley   +1 more source

Foreign Direct Investment and Maritime Transportation Infrastructure: Competition Effects Under the Belt and Road Initiative

The World Economy, EarlyView.
ABSTRACT In this paper, we analyse the determinants of maritime connections, with a special focus on the importance of foreign direct investments (FDI) in improving maritime transportation networks and in restructuring them. We are also interested in how China, in particular, impacts countries' integration to global supply chains through maritime ...
Natalia Vechiu, Manish Kumar Sharma
wiley   +1 more source

Russian statehood and Ukrainian separatism in Russian Emigrant prince A. M. Volkonsky’s study “Historical Truth and Ukrainophile Propaganda”

Управление
The purpose of the study is to analyze the opinion of one of the prominent representatives of the Russian post-October emigration of the 1920s and 1930s, Prince A. M. Volkonsky, on the foundations of Russian statehood and Ukrainian separatism, set out in
N. A. Omelchenko, E. P. Kazban, A. V. Kirka, T. V. Rastimeshina   +3 more
doaj   +1 more source

Identification of Shared Genetic Variants and Haplotypes Associated With Schizophrenia and Depression

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Introduction Depression is highly prevalent among individuals with schizophrenia and significantly influences disease progression, treatment response, and risk of suicide. Despite its clinical relevance, the genetic underpinnings of depression comorbidity in schizophrenia remain poorly understood.
Morteza Gholami
wiley   +1 more source

Dynamic Fusion of Genomics and Functional Network Connectivity in UK Biobank Reveals Schizophrenia‐Related SNP Manifolds

Human Brain Mapping, Volume 47, Issue 6, April 15, 2026.
A joint ICA (jICA)‐based “dynamic fusion” framework to identify dynamically tuned SNP manifolds by linking static SNPs to dynamic functional information of the brain. ABSTRACT Many mental disorders show strong genetic influence. In parallel, dynamic functional network connectivity (dFNC) has shown high sensitivity to brain changes related to mental ...
Jiayu Chen, Armin Iraji, Zening Fu, Marlena Duda, Pablo Andrés‐Camazón, Bishal Thapaliya, Jingyu Liu, Vince D. Calhoun   +7 more
wiley   +1 more source

Projects and Realities of Forming a Great Eurasian Space

Евразийская интеграция: экономика, право, политика
Aim. Analyze three options for the development and construction of the Eurasian space (Russian, Chinese and Turkic) and identify the advantages and risks associated with both the expansion of integration processes and external influence on states that ...
A. A. Akaev, I. F. Kefeli
doaj   +1 more source

Schizophrenia Genetics Modulates Clinical Depressive Features

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 201, Issue 3, Page 180-193, April 2026.
ABSTRACT Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.
Alessandro Serretti, Daniel Souery, Siegfried Kasper, Joseph Zohar, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Raffaele Ferri, Giuseppe Fanelli, Chiara Fabbri, Raffaella Zanardi, Francesco Benedetti, Bernhard T. Baune, Julien Mendlewicz   +13 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
We identified shared genetic architecture and bidirectional causal associations between epilepsy and major psychiatric disorders, highlighting MAPK signaling as a potential convergent pathway. ABSTRACT Background Growing evidence suggests that epilepsy and psychiatric disorders may share common genetic underpinnings, yet the precise etiological ...
Xia Feng, Huan Yao, Gui Xiao
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 168-189, December 2025.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source