Results 31 to 40 of about 471 (105)

The Role of SLC39A8.p.(Ala391Thr) in Schizophrenia Symptom Severity and Cognitive Ability: Cross‐Sectional Studies of Schizophrenia and the General UK Population

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 135-146, October 2025.
ABSTRACT The missense SNP NC_000004.12:g.102267552C>T (also known as SLC39A8.p.(Ala391Thr), rs13107325) in SLC39A8 encodes a zinc transporter. This SNP has been linked to schizophrenia and is the likely causal variant for one of the genome‐wide association loci associated with the disorder. Using regression analyses, we tested whether the schizophrenia‐
Sophie E. Smart, Sophie E. Legge, Eilidh Fenner, Antonio F. Pardiñas, Grace Woolway, Amy J. Lynham, Valentina Escott‐Price, Jeremy Hall, Lawrence Wilkinson, Peter Holmans, Michael C. O'Donovan, Michael J. Owen, James T.R. Walters   +12 more
wiley   +1 more source

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, Volume 182, Issue 19, Page 4710-4728, October 2025.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source

A Transcriptome‐Wide Mendelian Randomization Study in Isolated Human Immune Cells Highlights Risk Genes Involved in Viral Infections and Potential Drug Repurposing Opportunities for Schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 6, Page 19-31, September 2025.
ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey, Liam Gaziano, Preethi Eldi, Catherine Toben, Beben Benyamin, S. Hong Lee, Elina Hyppönen   +6 more
wiley   +1 more source

Correcting for Genomic Inflation Leads to Loss of Power in Large‐Scale Genome‐Wide Association Study Meta‐Analysis

Genetic Epidemiology, Volume 49, Issue 6, September 2025.
ABSTRACT Inflation in genome‐wide association studies (GWAS) summary statistics represents a major challenge, for which correction methods have been developed. These include the genomic control (GC) method, which uses the λ‐value to correct summary statistics, and the linkage disequilibrium score regression (LDSR) method, which uses the LDSR intercept.
Archit Singh, Lorraine Southam, Konstantinos Hatzikotoulas, Nigel W. Rayner, Ken Suzuki, Henry J. Taylor, Xianyong Yin, Ravi Mandla, Alicia Huerta‐Chagoya, Andrew P. Morris, Eleftheria Zeggini, Ozvan Bocher   +11 more
wiley   +1 more source

Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 5, July 2025.
ABSTRACT A large proportion of patients undergoing cognitive behavior therapy (CBT) for obsessive‐compulsive disorder (OCD) do not respond sufficiently to treatment. Identifying predictors for change in symptom severity after treatment could inform clinical decision‐making, allow for better‐tailored interventions, and avoid treatment failure.
Julia Bäckman, John Wallert, Matthew Halvorsen, Bjorn Roelstraete, Elles de Schipper, Nora I. Strom, Thorstein Olsen Eide, Kira D. Höffler, Manuel Mattheisen, Bjarne Hansen, Gerd Kvale, Kristen Hagen, Jan Haavik, Nordic OCD and Related Disorders Consortium (NORDiC), Julia Bäckman, Long Long Chen, James J. Crowley, Elles de Schipper, Diana Pascal, Jan Haavik, Kristen Hagen, Matthew W. Halvorsen, Bjarne Hansen, Kira D. Höffler, Fredrik Johansson, Anna K. Kähler, Elinor K. Karlsson, Gerd Kvale, Paul Lichtenstein, Kerstin Lindblad‐Toh, Manuel Mattheisen, David Mataix‐Cols, Kathleen Morrill, Christian Rück, Thorstein Olsen Eide, Nora I. Strom, John Wallert, David Mataix‐Cols, Christian Rück, James J. Crowley   +39 more
wiley   +1 more source

Cross‐Sectional Brain Age Assessments Are Limited in Predicting Future Brain Change

Human Brain Mapping, Volume 46, Issue 6, April 15, 2025.
Multimodal imaging data of 39,325 UK Biobank participants with 2,520 follow‐ups provide insufficient evidence to conclude that brain age reflects the rate of anatomical brain aging. However, modality‐specific differences in brain ages reflect the cross‐sectional state of the brain, highlighting diffusion and multimodal MRI brain age as potentially ...
Max Korbmacher, Didac Vidal‐Pineiro, Meng‐Yun Wang, Dennis van der Meer, Thomas Wolfers, Hajer Nakua, Eli Eikefjord, Ole A. Andreassen, Lars T. Westlye, Ivan I. Maximov   +9 more
wiley   +1 more source

Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis. [PDF]

Psychol Med
Barr PB, Neale ZE, Bigdeli TB, Chatzinakos C, Harvey PD, Peterson RE, Meyers JL.   +6 more
europepmc   +1 more source

Activation of MyD88/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin. [PDF]

JID Innov
Trubetskoy D, Grudzien PK, Klopot A, Tsoi LC, Kundu RV, Perez White BE, Budunova I.   +6 more
europepmc   +1 more source

Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity. [PDF]

Psychol Med
Ren H, Liu Y, Huang Y, Tang Y, Xiao L, Wu Y, Liu S, Yin Y, Ma Q, Dai M, Tao S, Xie M, Li M, Li T, Wang Q.   +14 more
europepmc   +1 more source

Familial coaggregation and shared genetic loading of mental disorders and cardiovascular diseases. [PDF]

Psychol Med
Chen PC, Pan YJ, Lin MC, Su MH, Fan CC, Wu CS, Wang SH.   +6 more
europepmc   +1 more source