Results 31 to 40 of about 3,450 (152)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Intercultural communication experience [PDF]

, 2017
The urgency of the problem under study lies in the fact that the problems of intercultural communication of the peoples of Russia, which were on the agenda during the ХIХth - early XXth centuries, did not lose their relevance in the 21st century.
Brodovskaya, Lyudmila N., Buravleva, Vera V., Fazliev, Aivaz M., Galimzyanova, Liliya R.   +3 more
core  

Compositional Analysis of the High Molecular Weight Ethylene Oxide Propylene Oxide Copolymer by MALDI Mass Spectrometry

, 2012
The composition of narrow distribution poly ethylene oxide-propylene oxide copolymer (Mw ~ 8700 Da) was studied using matrix assisted laser desorption ionization (MALDI) mass spectrometry.
Houshia, Orwa Jaber, Wilkins, Charles
core   +1 more source

Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Neuropsychiatric symptoms (NPSs) occur in up to 85% of Alzheimer's disease (AD) cases. Current treatments – repurposed from psychiatric disorders despite limited understanding of etiologic overlap – are often ineffective. METHODS To characterize the genetic overlap between AD and major psychiatric disorders and identify shared ...
Ajneesh Kumar, Nicholas R. Ray, Jiji T. Kurup, Pamela Del Rosario, Masood Manoochehri, Colin Stein, Alyssa N. De Vito, Brenna Cholerton, Robert A. Sweet, Phil L. de Jager, Hans‐Ulrich Klein, Michael L. Cuccaro, Gary W. Beecham, Edward D. Huey, Christiane Reitz   +14 more
wiley   +1 more source

A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles [PDF]

, 2010
The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated ...
Eavarone, David A., Haller, Toomas, Sasisekharan, Ram, Soundararajan, Venkataramanan   +3 more
core   +1 more source

Projects and Realities of Forming a Great Eurasian Space

Евразийская интеграция: экономика, право, политика
Aim. Analyze three options for the development and construction of the Eurasian space (Russian, Chinese and Turkic) and identify the advantages and risks associated with both the expansion of integration processes and external influence on states that ...
A. A. Akaev, I. F. Kefeli
doaj   +1 more source

Черты евроазиатских традиций в системе западного традиционализма в первой половине ХХ века [PDF]

, 2009
In the article author suggests version about presence of own set of traditions in classical Eurasian project. Notions of «traditionalism» and «conservatism» are considered in it.
Chanchikova, Julia T., Ю.Т.Чанчикова   +1 more
core  

A simple molecular modeling method for the characterization of polymeric drug carriers [PDF]

, 2013
A simple molecular modeling method for the characterization of polymeric drug carriers is presented. Six biodegradable polymers have been investigated as drug carriers using molecular simulations: l-polylactide, d-polylactide, chitosan, polyglycolic acid,
Macháčková, Miroslava, Tokarský, Jonáš, Čapková, Pavla   +2 more
core   +1 more source

Shared Genetic Basis and Causality Between Epilepsy and Psychiatric Disorders: Evidence From a Comprehensive Genetic Analysis

Brain and Behavior, Volume 16, Issue 2, February 2026.
We identified shared genetic architecture and bidirectional causal associations between epilepsy and major psychiatric disorders, highlighting MAPK signaling as a potential convergent pathway. ABSTRACT Background Growing evidence suggests that epilepsy and psychiatric disorders may share common genetic underpinnings, yet the precise etiological ...
Xia Feng, Huan Yao, Gui Xiao
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 168-189, December 2025.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source