Results 131 to 140 of about 326,728 (258)

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

CCL21-Ser expression in melanoma cells recruits CCR7⁺ naïve T cells to tumor tissues and promotes tumor growth. [PDF]

Cancer Sci, 2023
Miyamoto M, Kawato Y, Fujie R, Kurowarabe K, Fujiwara K, Nobusawa R, Hayashi R, Iida K, Ohigashi I, Hayasaka H.   +9 more
europepmc   +1 more source

Analysis of Trim5α mRNA Levels in Naïve and Memory CD4 T Cells

, 2013
(A) Trim5α mRNA levels in naïve CD4 T cells (CD45RO-CD27+) and memory CD4 T cells (CD45RO+) obtained from healthy controls.(B) Average Trim5α mRNA levels in naïve and memory CD4 T cells during the course of infection from HIV-1 infected individuals ...
Hanneke Schuitemaker (85702), Daniëlle van Manen (85698), Corrine Beugeling (85700), Maarten A. N Rits (85699), Karel van Dort (85701), Neeltje A Kootstra (85703)   +5 more
core   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Blood CD8+ Naïve T-Cells Identify MS Patients with High Probability of Optimal Cellular Response to SARS-CoV-2 Vaccine. [PDF]

Vaccines (Basel), 2023
Rodero-Romero A, Sainz de la Maza S, Fernández-Velasco JI, Monreal E, Walo-Delgado PE, Chico-García JL, Villarrubia N, Rodríguez-Jorge F, Rodríguez-Ramos R, Masjuan J, Costa-Frossard L, Villar LM.   +11 more
europepmc   +1 more source

Analysis of naïve lung CD4 T cells provides evidence of functional lung to lymph node migration

, 2013
The proportion of CD4 T cells with phenotypic and functional properties of naïve cells out of total CD4 T cells is similar in the lung parenchyma and lymph nodes.
Stephane M. Caucheteux, Torabi-Parizi, P., William E. Paul, Paul, William E, Caucheteux, Stephane M, Caucheteux, Stephane, Paul, W. E., Parizad Torabi-Parizi, Torabi-Parizi, Parizad   +8 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Viability of PB and CB naïve and memory T cells after treatment with CAMPATH.

, 2014
A, C, E, and G show the percentage of apoptotic cells in resting/activated naïve CD4, naïve CD8, memory CD4, and memory CD8 T cells respectively. B, D, F, and H show the percentage of necrosis in resting/activated naïve CD4, naïve CD8, memory CD4, and ...
Alejandro Madrigal (428287), Bronwen E. Shaw (602212), Paul Veys (474762), Kwee Yong (309403), Fuiyee Lee (602211), Martha Luevano (516259), Aurore Saudemont (516266)   +6 more
core   +1 more source

Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.

, 2010
Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology.
Couper, Kevin N, Riley, Eleanor M, Stumhofer, Jason S, Hafalla, Julius CR, Emily Gwyer Findlay, Findlay, Emily Gwyer, Saris, Christiaan J, Julius C. R. Hafalla, de Souza, J Brian, Christopher A. Hunter, Saris, Christiaan J., Stumhofer, Jason S., Hafalla, Julius C R, Hunter, Christopher A, Rachel Greig, Greig, Rachel, J. Brian de Souza, De Souza, J. Brian, Kevin N. Couper, Eleanor M. Riley, Riley, Eleanor M., Jason S. Stumhofer, Christiaan J. Saris, Hunter, Christopher A., Couper, Kevin N.   +24 more
core   +1 more source