Results 71 to 80 of about 326,728 (258)

Helios enhances the preferential differentiation of fetal naïve CD4+ T cells into regulatory T cells [PDF]

, 2019
T cell receptor (TCR) stimulation and cytokine cues drive the differentiation of CD4+ naïve T cells into effector T cell populations with distinct pro-inflammatory or regulatory functions.
Ng, Melissa
core  

Type I interferon signaling is required for Ly6C expression on naïve CD8 T cells.

, 2023
(A) Experimental design. Mice were infected with LCMV-Arm and 3 days later serum and naïve CD8 T cells were analyzed. (B) Amount of IFNα (pg/mL) within the serum of naïve and LCMV-Arm infected mice 3 days post-infection.
Tiffany K. Ybarra (17138446), Thomas S. Griffith (8876915), Vladimir P. Badovinac (17138449), Isaac J. Jensen (4437454), John T. Harty (16852938), Gail A. Bishop (10076752), Patrick W. McGonagil (17138443), Roger R. Berton (17138440)   +7 more
core   +1 more source

INF-γ/TGF-β1-primed umbilical cord mesenchymal stem cells boost the T-lymphocytes activity: Modulation of CD25 expression and IL-6 secretion

International Journal of Immunopathology and Pharmacology
Background: Mesenchymal stromal/stem cells (MSCs) have potent immunomodulatory abilities, particularly in a milieu of hyperactive immune system, through secreting a number of cytokines, growth factors, bioactive compounds and peptides, and by cell-cell ...
Abdulrahman H Almaeen, Heba M Saad-Eldien, Hala Gabr   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells.

, 2008
Promising immunotherapeutic tools for T cell-mediated pathologies are alternatively activated dendritic cells (aaDC), which exert their effect through the regulation and tolerization of T cells. As naïve and memory T cells have different susceptibilities
Hilkens, Catharien M U, Diboll, Julie, Wang, Xiao-Nong, Haniffa, Muzlifah A, Isaacs, John D, Sayers, Bethan L, Swan, David, Anderson, Amy E   +7 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A multi-omic analysis of human naïve CD4+ T cells [PDF]

, 2015
Background: Cellular function and diversity are orchestrated by complex interactions of fundamental biomolecules including DNA, RNA and proteins. Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively ...
Min-Sik Kim, Jun Zhong, Tai-Chung Huang, Scott, Alan F., Murakami, Peter N., Ishihama, Yasushi, Arivusudar Marimuthu, Shi, Leming, Praveen Kumar, Irizarry, Rafael, Prasad, T. S Keshava, Kim, Min Sik, Dhanashree S. Kelkar, Sahasrabuddhe, Nandini A., Babylakshmi Muthusamy, Shaw, Patrick G., Gowda, Harsha, Iwasaki, Mio, Harsha Gowda, Akhilesh Pandey, Rafael Irizarry, Caitlyn Bowman, Nandini A. Sahasrabuddhe, Patrick G. Shaw, Rajesh Raju, Drake, Charles G., Christopher J. Mitchell, Srikanth S. Manda, Marchionni, Luigi, Zhong, Jun, Peter N. Murakami, Getnet, Derese, Thierry-Mieg, Danielle, Nirujogi, Raja Sekhar, Kumar, Praveen, Raju, Rajesh, Cutler, Jevon, Marimuthu, Arivusudar, Chaerkady, Raghothama, Ludmila Danilova, Huang, Tai Chung, Raja Sekhar Nirujogi, Jean Thierry-Mieg, Leslie Cope, Yasushi Ishihama, Muthusamy, Babylakshmi, Derese Getnet, Pandey, Akhilesh, Luigi Marchionni, Jevon Cutler, T. S. Keshava Prasad, Wu, Xinyan, Xinyan Wu, Kelkar, Dhanashree S., Alan F. Scott, Mitchell, Christopher J., Sneha M. Pinto, Mio Iwasaki, Leming Shi, Charles Wang, Thierry-Mieg, Jean, Pinto, Sneha M., Raghothama Chaerkady, Cope, Leslie, Wang, Charles, Charles G. Drake, Danielle Thierry-Mieg, Danilova, Ludmila, Manda, Srikanth S., Bowman, Caitlyn   +69 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Early growth response genes -2 and -3 are essential for optimal immune responses [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Early Growth Response Genes (EGR) is a family of four transcription factors containing a unique zinc finger domain.
Ghaffari, Emma Louise Marie
core