Results 81 to 90 of about 326,728 (258)

Loss of FRCs is associated with loss of naïve T cells within LTs.

, 2012
A. Confocal images of LN sections from subjects at different stage of HIV infection triple immunofluorescently stained for TUNEL (green), CD45RA (red) and CD3 (Blue), showing the gradual loss of CD45RA+CD3+ naïve T cells is associated increased apoptosis
Timothy W. Schacker (189171), Ashley T. Haase (189177), Jeffrey G. Chipman (189162), Ming Zeng (189146), Cavan S. Reilly (127576), Peter J. Southern (189151), Greg J. Beilman (189157)   +6 more
core   +1 more source

VIPER regulates naive T cell activation and effector responses: Implication in TLR4 associated acute stage T cell responses

Scientific Reports, 2018
Naive T cells are known to express the modest level of TLR4 while it is known to go down during TCR activation. However, information towards the requirement of TLR4 signaling during TCR or mitogenic activation of naive wild-type T cells remains scanty ...
Subhransu Sekhar Sahoo, Belluru M. Pratheek, Vikram S. Meena, Tapas Kumar Nayak, P. Sanjai Kumar, Saumya Bandyopadhyay, Prasanta Kumar Maiti, Subhasis Chattopadhyay   +7 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Correlation between the percentage of Ki-67-positive cells in naïve, memory, or naïve plus memory CD4⁺ T cells and the percentage of naïve cells in CD4⁺ T cells.

, 2014
Splenocytes isolated from Balb/c and NOD mice were stained with APC-conjugated anti-CD4, FITC-conjugated anti-CD44, PE-conjugated anti-CD45RB, and Per-CP-conjugated anti-Ki-67, and then 30,000 cells were analyzed with flow cytometry with gating performed
Jui-Hung Yen (143537), Wen-Chi Lin (527519), Ting-Ting Sheu (195133), Bor-Luen Chiang (277733)   +3 more
core   +1 more source

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree, Beatrice Suero, Sarah Walsh, Romain Marignier, John W. Lindsey, Ho Jin Kim, Dewei She, Daniel Cimbora, Dustin Cavida, Friedemann Paul   +9 more
wiley   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Multimodal Data‐Driven Microstructure Characterization

Advanced Engineering Materials, EarlyView.
A self‐consistent autonomous workflow for EBSP‐based microstructure segmentation by integrating PCA, GMM clustering, and cNMF with information‐theoretic parameter selection, requiring no user input. An optimal ROI size related to characteristic grain size is identified.
Qi Zhang, Santiago Benito, Özge Özgün, Sebastian Weber, Markus Stricker   +4 more
wiley   +1 more source

Homeostatic proliferation and survival of naïve and memory T cells

, 2009
The immune system relies on homeostatic mechanisms in order to adapt to the changing requirements encountered during steady-state existence and activation by antigen.
Létourneau, Sven, Létourneau, S., Boyman, Onur, Carsten Krieg, Krieg, Carsten, Onur Boyman, Boyman, O., Krieg, C., Sprent, J., Sven Létourneau, Sprent, Jonathan, Jonathan Sprent   +11 more
core   +1 more source

Hematopoietic Stem Cell Transplantation Restores Naïve T-Cell Populations in Atm-Deficient Mice and in Preemptively Treated Patients With Ataxia-Telangiectasia

Frontiers in Immunology, 2019
Background: Ataxia-telangiectasia (A-T) is a multisystem disorder with progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and increased cancer susceptibility.
Ruth Duecker, Patrick C. Baer, Aileen Buecker, Sabine Huenecke, Lisa-Marie Pfeffermann, Ute Modlich, Shahrzad Bakhtiar, Peter Bader, Stefan Zielen, Ralf Schubert   +9 more
doaj   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source